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Amy S. Colwell, MDa. , Jonathan D'Cunha, MD, PhDb. , Sara O

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Presentation on theme: "Amy S. Colwell, MDa. , Jonathan D'Cunha, MD, PhDb. , Sara O"— Presentation transcript:

1 Synovial sarcoma of the pleura: A clinical and pathologic study of three cases 
Amy S. Colwell, MDa*, Jonathan D'Cunha, MD, PhDb*, Sara O. Vargas, MDa, Benjamin Parker, BSb, Paola Dal Cin, PhDc, Michael A. Maddaus, MDb  The Journal of Thoracic and Cardiovascular Surgery  Volume 124, Issue 4, Pages (October 2002) DOI: /mtc Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

2 Fig. 1 Pleural monophasic synovial sarcoma. Selected sections of conventional CT scan of chest from patient 1 showing large peripheral homogeneous soft tissue mass growing within pleural cavity. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 2 Synovial sarcoma, monophasic type. Hematoxylin and eosin-stained section from patient 1 depicting monophasic synovial sarcoma (original magnification ×40). Tumor cells are plump, spindle-shaped, and arranged in short fascicles, typical of classic monophasic variant. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

4 Fig. 3 Synovial sarcoma, monophasic type. Hematoxylin and eosin-stained section from patient 2 depicting poorly differentiated monophasic synovial sarcoma with round cells showing high nucleus-to-cytoplasm ratio and absence of fascicular growth (original magnification ×40). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

5 Fig. 4 Synovial sarcoma, biphasic type. Hematoxylin and eosin-stained section from patient 3. Tumor is biphasic and shows glandular epithelium interspersed among spindle-shaped cells (original magnification ×40). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

6 Fig. 5 FISH analysis. A, Patient 1, interphase nucleus with normal hybridization pattern for CEPX (orange) and YAC770c4 (green). B, Patient 2, interphase nucleus with abnormal hybridization pattern of colocalized YAC770c4 (green) and CEPX (orange) signals indicating 5(X;18). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

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