1. Cardiac Sarcomas: An Update
Augusto Orlandi, MD, Amedeo Ferlosio, MD, Mario Roselli, MD, Luigi Chiariello, MD, Luigi G. Spagnoli, MD 
Journal of Thoracic Oncology 
Volume 5, Issue 9, Pages (September 2010)
DOI: /JTO.0b013e3181e59a91
Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

2. FIGURE 1
A, Example of cardiac angiosarcoma; (B) macroscopically, cut surface appears reddish-brown from alternating solid and hemorrhagic areas. Microscopically, the tumor shows (C) well-differentiated areas with vascular channel lined by atypical endothelial cells, and (D) solid areas from accumulation of large epithelioid cells with marked pleomorphism, mitosis (arrow) and atypical cells with vacuolized cytoplasm containing erythrocytes (*) (Hematoxylin and Eosin).
Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181e59a91)
Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

3. FIGURE 2
A, Two-dimensional echocardiography reveals a large undifferentiated pleomorphic sarcoma/MFH (*) occupying the right ventricle (RV). B, Autoptic examination of the heart of the patient shows a white-yellowish mass with areas of necrosis (*) widely infiltrating the myocardium and the interventricular septum (IVS). C and D, Histologically, the undifferentiated pleomorphic sarcoma/MFH is constituted by highly pleomorphic spindle or ephiteliod cells with abundant eosinophilic cytoplasm and interspersed giant or multinucleated cells (arrows) arranged in vaguely storiform fashion. E, Undifferentiated pleomorphic sarcoma/MFH, small-cell subtype. F, Undifferentiated pleomorphic sarcoma/MFH with areas of chondroid differentiation (**) (Hematoxylin and Eosin). LA, left atrium; LV, left ventricle; RA, right atrium; MFH, malignant fibrous histiocytoma.
Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181e59a91)
Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

4. FIGURE 3
A and B, An example of cardiac leiomyosarcoma, microscopically composed of variably oriented bundles of pleomorphic spindle cells with blunt-ended nuclei (Hematoxylin and Eosin). Immunohistochemistry reveals the presence of diffuse (C) α-smooth muscle actin and (D) desmin-positive cells.
Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181e59a91)
Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

5. FIGURE 4
An example of cardiac myxosarcoma, microscopically characterized by (A) prominent elongated, curvilinear thin-walled blood vessels and (B) hypocellular areas with spindle hyperchromatic cells embedded in abundant myxoid matrix; (C) in other areas, myxosarcoma seems hypercellular with herringbone-like growth pattern (Hematoxylin and Eosin). D, Ultrastructural features of a myxosarcomatous cell, with scarce cytoplasm, prominent nucleoli, and collagen bundles intimately associated to the plasmalemma (transmission electron microscopy).
Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181e59a91)
Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions