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Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization 

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Presentation on theme: "Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization "— Presentation transcript:

1 Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization  Christopher D. Owens, MD, MSc, Warren J. Gasper, MD, Joy P. Walker, MD, Hugh F. Alley, BA, Michael S. Conte, MD, S. Marlene Grenon, MD  Journal of Vascular Surgery  Volume 59, Issue 4, Pages (April 2014) DOI: /j.jvs Copyright © 2014 Society for Vascular Surgery Terms and Conditions

2 Fig 1 The Bullfrog microinfusion catheter (A). Diffusion grading scale (B). A is supplied courtesy of Mercator Medsystems (San Leandro, Calif). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Endovascular treatment with adjunctive dexamethasone. This is a 49-year-old man with severe disabling claudication and a 16-cm superficial femoral artery (SFA) occlusion. Following securing access across the lesion with a glide wire, the lesion was treated with balloon angioplasty. Following successful angioplasty, four 1.0-mL injections were performed along the length of the lesion (only three shown). In the left panel, there is a discreet contrast blush seen at each injection site. Note that the contrast appears circumferentially at each injection site. Three minutes later, the drug-contrast admixture can be seen to have diffused longitudinally to fully cover the treated segment. The patient is now 2 years from his index procedure and remains patent and complains of only mild claudication with heavy exertion. He has an ankle-brachial index (ABI) of 1.09 and a peak systolic velocity ratio of less than 2.5. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Examples of typical dexamethasone-contrast diffusion patterns in patients treated in this study. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

5 Fig 4 The mean ankle-brachial index (ABI) is significantly improved from baseline across all time points postprocedure. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

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