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Fig. 3. The effects of DCA on hemodynamic and functional end points and their association with genetic factors (variants of the SIRT3 and UCP2 genes) that.

Published byVetle Marthinsen Modified over 5 years ago

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Presentation on theme: "Fig. 3. The effects of DCA on hemodynamic and functional end points and their association with genetic factors (variants of the SIRT3 and UCP2 genes) that."— Presentation transcript:

1 Fig. 3. The effects of DCA on hemodynamic and functional end points and their association with genetic factors (variants of the SIRT3 and UCP2 genes) that cause resistance to DCA. The effects of DCA on hemodynamic and functional end points and their association with genetic factors (variants of the SIRT3 and UCP2 genes) that cause resistance to DCA. (A) mPAP, PVR, and 6-min walk performance of DCA-treated patients. Statistical significance was assessed using before-after paired t test (P < 0.05). The means ± SEM before and after DCA treatment and the P values are shown in each graph. (B) Scatter plots of the DCA-induced changes in mPAP, PVR, and 6-min walk, separated by the SNP score status of each patient. Statistical significance was assessed using a Spearman’s correlation test and rS, and P values are shown in each graph. Highlighted region identifies seven patients who exhibited a significant decrease in the mPAP (>5 mmHg decrease) associated with an increase or no change in the cardiac output, suggestive of a clinically meaningful response. Plots of the DCA-induced change in mPAP, PVR, and 6-min walk (means ± SEM) over the SNP score are shown on the right. Evangelos D. Michelakis et al., Sci Transl Med 2017;9:eaao4583 Published by AAAS

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