1. Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor? 
Maria A. Curotto de Lafaille, Juan J. Lafaille 
Immunity 
Volume 30, Issue 5, Pages (May 2009)
DOI: /j.immuni
Copyright © 2009 Elsevier Inc. Terms and Conditions

2. Figure 1 Thymic and Peripheral Generation of Foxp3+ Treg Cells
Natural Treg (nTreg) cells differentiate in the thymus and migrate to peripheral tissues. Adaptive Foxp3+ Treg (iTreg) cells differentiate in secondary lymphoid organs and tissues. The peripheral population of Foxp3+ Treg cells comprises both nTreg and iTreg cells. It is very likely that nTreg and Foxp3+ iTreg cells differ in their TCR repertoire because iTreg cells are derived from mature peripheral naive CD4+ cells.
Immunity  , DOI: ( /j.immuni )
Copyright © 2009 Elsevier Inc. Terms and Conditions