1. Fig. 2. Adenosine-induced SAN dysfunction recorded by optical mapping and SAN electrograms in ex vivo human hearts.
Adenosine-induced SAN dysfunction recorded by optical mapping and SAN electrograms in ex vivo human hearts. (A) Left: Heart preparation showing the location of the SAN and bipolar catheter. Circles #1 and #2 indicate SAN leading pacemaker and EAS (asterisk), respectively. The orange arrow indicates the preferential SACP. Right: OAPs of extracted SAN (blue) and atria (green) with SAN electrogram (EG) (black) during adenosine (10 μM) perfusion. (B) Atrial ECG and SAN electrogram recordings of adenosine (10 μM)–induced bradycardia in heart , 2:1 exit block followed by complete exit block in heart , and SAN arrest in heart Purple box in (B) shows SAN beat presented in (A). (C) SAN and atria activation maps and OAPs during baseline, adenosine (10 μM), and adenosine (100 μM) + tertiapin in heart , respectively. (D) Quantification of adenosine-induced SAN conduction and automaticity inhibition restored by tertiapin. Bar graphs summarize the average drug effect; white numbers show the number of hearts used. Data are means ± SD. P values were determined by analysis of variance (ANOVA) after Tukey’s adjustment. Ado, adenosine; HR, heart rate; IVC, inferior vena cava; SACTsr, sinoatrial conduction time during sinus rhythm; SR, sinus rhythm.
Ning Li et al., Sci Transl Med 2017;9:eaam5607
Published by AAAS