1. Volume 67, Issue 1, Pages 237-247 (January 2005)
Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats 
Laura G. Sanchez-Lozada, Edilia Tapia, Jose Santamaria, Carmen Avila-Casado, Virgilia Soto, Tomas Nepomuceno, Bernardo Rodriguez-Iturbe, Richard J. Johnson, Jaime Herrera-Acosta, Ph. D. 
Kidney International 
Volume 67, Issue 1, Pages (January 2005)
DOI: /j x
Copyright © 2005 International Society of Nephrology Terms and Conditions

2. Figure 1
Effect of afferent arteriole thickening induced by hyperuricemia on hemodynamic parameters in normal rats. Values of serum uric acid positively correlated with AA media/lumen (A). Arteriolopathy was associated with glomerular pressure (B). Thickening of AA negatively correlated with SNGFR (C) and positively correlated with afferent resistance (D). ^;, control; •, oxonic acid; ^, OA+ allopurinol.
Kidney International  , DOI: ( /j x)
Copyright © 2005 International Society of Nephrology Terms and Conditions

3. Figure 2
Effect of afferent arteriole thickening induced by hyperuricemia in RK rats. Values of serum uric acid positively correlated with AA media/lumen (A). Arteriolopathy was associated with glomerular pressure (B). Tubulointerstitial infiltration of CD5+ cells (lymphocytes) correlated with AA thickening (C). Glomerular pressure correlated with tubulointerstitial fibrosis (D). □, control RK; ▪, oxonic acid; , OA+ allopurinol.
Kidney International  , DOI: ( /j x)
Copyright © 2005 International Society of Nephrology Terms and Conditions

4. Figure 3
Representative microphotographs of afferent arteriole morphology. PAS stain and alpha-actin smooth muscle antibody (1000×). Normal rats on normal salt diet (A), oxonic acid (C), OA+ allopurinol (E); control (RK) (B), RK + oxonic acid (D), RK + OA + allopurinol (F).
Kidney International  , DOI: ( /j x)
Copyright © 2005 International Society of Nephrology Terms and Conditions