1. Cartilage and Bone
VIBS 443/602

2. OBJECTIVES GENERAL ORGANIZATION MECHANISM OF GROWTH
CHARACTERISTICS OF CELLS

3. CELLS OF CT FIBROBLASTS MESENCHYMAL CELLS and RBC ADIPOSE CELLS
MACROPHAGE
PLASMA CELLS
MAST CELLS and WBC
CHONDROBLASTS
CHONDROCYTES
OSTEOBLASTS
OSTEOCYTES
OSTEOCLASTS

4. TYPES OF CARTILAGE
HYALINE CARTILAGE
ELASTIC CARTILAGE
FIBROCARTILAGE

8. primary spongiosa of the Fetal finger
220
primary spongiosa of the Fetal finger

9. Fetal elbow
194

10. Fetal elbow
194

11. 421
Tibia, fetal

12. 133
Trachea, monkey

13. Appositional growth of cartilage
EM 11: cartilage
Chondrocyte
Fibroblast
Appositional growth region
Type I collagen
Type II collagen

14. interstitial growth of cartilage
EM 13: cartilage interstitial growth of chondrocytes
2 daughter chondrocytes resulting from interstitial growth
Rough endoplasmic reticulum

15. HYALINE CARTILAGE
EPIPHYSEAL PLATE, RESPONSIBLE FOR LONGITUDINAL GROWTH OF LONG BONES

16. cartilage growth in endochondral bone formation of the Fetal finger
220
cartilage growth in endochondral bone formation of the Fetal finger

17. OSTEOBLAST
OSTEOCLAST

18. OSTEOCLAST
OSTEOBLAST

19. Elastic cartilage in pina of ear #19762
Connective
tissue
Connective
tissue
epithelium
epithelium
Elastic cartilage
Elastic cartilage

20. FIBROCARTILAGE
INTERMEDIATE BETWEEN DENSE REGULAR CONNECTIVE TISSUE AND HYALINE CARTILAGE
NO PERICHONDRIUM

21. Fibrocartilage of Fetal elbow
194
Fibrocartilage of Fetal elbow
Fibrocartilage
Fibrocartilage

22. Fibrocartilage of Fetal elbow
194
Fibrocartilage of Fetal elbow
Fibrocartilage

23. Fibrocartilage of Fetal elbow
194
Fibrocartilage of Fetal elbow
Fibrocartilage

24. Fetal finger – fibroblasts in tendon
220
Fetal finger – fibroblasts in tendon
Tendon
Fibrocartilage

25. endochondral
bone formation

26. CELLS OF BONE OSTEOBLASTS - SECRETE OSTEOID - BONE OSTEOCYTE =
EXPAND BONE BY APPOSITIONAL GROWTH
OSTEOCYTE =
OSTEOBLAST
TRAPPED IN
MATRIX OF
BONE

27. APPOSITIONAL GROWTH
EM 12: osteoblast adjacent to osteoid; bone; RER and Golgi
Rough endoplasmic reticulum
Golgi
Osteoid
Nucleus of osteoblast

28. CELLS OF BONE

29. FUNCTIONS OF BONE CALCIUM REGULATION HEMOPOIESIS
Parathroid hormone (BONE RESORPTION)
Calcitonin (PREVENTS RESORPTION)
These HORMONES are INVOLVED IN TIGHT REGULATION as
1/4 OF FREE CA++ IN BLOOD IS EXCHANGED EACH MINUTE.
HEMOPOIESIS

30. COMPACT BONE
HAVERSIAN SYSTEMS - LAMELLAE OF BONE AROUND HAVERSIAN CANAL LINKED BY VOLKMANN’S CANAL

32. COMPACT BONE
REMODELING
Over time

33. COMPACT BONE
REMODELING

35. Slide 121: compact bone (unstained ground bone)
Blood vessel
Haversian canal
Interstitial system
Lacuna

36. Bone (unstained)
425

37. Bone (unstained)
425

38. Bone, rabbit femur
121

39. 121
Bone, rabbit femur

40. Bone, rabbit femur
121

41. Tibia, fetal
421

42. Osteoblasts in the Fetal jaw
195
Osteoblasts in the Fetal jaw

43. Osteoclasts, osteoblasts, and osteocytes in Fetal jaw
195
Osteoclasts, osteoblasts, and osteocytes in Fetal jaw
osteoclasts
osteocytes
osteoblasts

44. Rib
420

45. How many Osteoclasts of Fetal finger can you spot?
220
Osteoclasts

46. ENDOCHONDRAL (SPONGY/ CANCELLOUS) BONE FORMATION
CARTILAGE MODEL
CENTERS OF OSSIFICATION
PRIMARY CENTER OF OSSIFICATION
DIAPHYSIS
SECOND CENTER OF OSSIFICATION
CENTER OF EACH EPIPHYSIS

47. cartilage growth in endochondral bone formation of the Fetal finger
220
cartilage growth in endochondral bone formation of the Fetal finger

48. Articular surfaces of hyaline cartilage of the Fetal elbow
194
Articular surfaces of hyaline cartilage of the Fetal elbow

49. HISTOGENESIS OF BONE
INTRAMEMBRANOUS OSSIFICATION
FLAT BONES
OF SKULL

50. SKELETAL CONNECTIVE TISSUE

53. 420

54. 420

55. 420

56. 420

57. 420

58. 32583

59. 32583

60. 32583

61. 32583

62. 32583

63. 32583

64. 32583
Polychromatic
normoblast

65. 32583

66. 32583