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Analysis of High-Resolution HapMap of DTNBP1 (Dysbindin) Suggests No Consistency between Reported Common Variant Associations and Schizophrenia  Mousumi.

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Presentation on theme: "Analysis of High-Resolution HapMap of DTNBP1 (Dysbindin) Suggests No Consistency between Reported Common Variant Associations and Schizophrenia  Mousumi."— Presentation transcript:

1 Analysis of High-Resolution HapMap of DTNBP1 (Dysbindin) Suggests No Consistency between Reported Common Variant Associations and Schizophrenia  Mousumi Mutsuddi, Derek W. Morris, Skye G. Waggoner, Mark J. Daly, Edward M. Scolnick, Pamela Sklar  The American Journal of Human Genetics  Volume 79, Issue 5, Pages (November 2006) DOI: /508942 Copyright © 2006 The American Society of Human Genetics Terms and Conditions

2 Figure 1 A, Phylogenetic tree detailing the likely evolution of the five common haplotypes derived from tSNPs 2, 3, 5, 6, 8, and 11 (see table 3) in the CEU sample. Haplotype frequencies are shown at the bottom of the tree. Mutational events are detailed on the horizontal lines of the tree. The ancestral haplotype remains the most common haplotype in the CEU sample. Hap = haplotype. B, Each associated allele or haplotype from the six association studies of DTNBP1 and SCZ, mapped onto the phylogenetic tree. tSNPs are shown in parentheses, and haplotypes are shown in brackets. The American Journal of Human Genetics  , DOI: ( /508942) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Gene structure is seen, with vertical lines indicating exons. Markers are displayed relative to gene location. SNPs and their positions are given in table 4. LD structure (D′’) between marker pairs is indicated by the colored matrices. Haplotype blocks spanning the DTNBP1 gene are shown according to the method of Gabriel et al.25 Genomic positions are according to the NCBI Build 34, hg16 human genome assembly. The figure was generated using LocusView version 2.0. The American Journal of Human Genetics  , DOI: ( /508942) Copyright © 2006 The American Society of Human Genetics Terms and Conditions


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