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Muscle Wasting Is Associated With Mortality in Patients With Cirrhosis

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Presentation on theme: "Muscle Wasting Is Associated With Mortality in Patients With Cirrhosis"— Presentation transcript:

1 Muscle Wasting Is Associated With Mortality in Patients With Cirrhosis
Aldo J. Montano–Loza, Judith Meza–Junco, Carla M.M. Prado, Jessica R. Lieffers, Vickie E. Baracos, Vincent G. Bain, Michael B. Sawyer  Clinical Gastroenterology and Hepatology  Volume 10, Issue 2, Pages e1 (February 2012) DOI: /j.cgh Copyright © 2012 AGA Institute Terms and Conditions

2 Figure 1 Comparison of 2 cirrhotic patients with identical BMI (32 kg/m2). Abdominal CT images taken at third lumbar vertebrae. Red color indicates skeletal muscles: rectus abdominis, oblique and lateral abdominal muscles, psoas, and paraspinal muscles. The patient on the left is sarcopenic with L3 SMI of cm2/m2; patient on the right is not sarcopenic with L3 SMI of 70.8 cm2/m2. Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions

3 Figure 2 Dispersion graphs depicting correlations between L3 SMI and MELD score (A), Child–Pugh score (B), serum albumin (C), and serum sodium (D). Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions

4 Figure 3 Kaplan–Meier curve indicating the survival of patients with (- - -) and without (—) sarcopenia. The 6-month probability of survival was 71% and 90%, respectively (P = .005, log-rank test). One-year probability of survival was 53% and 83% in these same groups, but fewer patients were followed. Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions

5 Figure 4 ROC curve for predicting 3- and 6-month mortality for MELD, Child–Pugh score, serum sodium, and L3 SMI. Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh ) Copyright © 2012 AGA Institute Terms and Conditions


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