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Impact of monovalent rotavirus vaccine on diarrhoea-associated post-neonatal infant mortality in rural communities in Malawi: a population-based birth.

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Presentation on theme: "Impact of monovalent rotavirus vaccine on diarrhoea-associated post-neonatal infant mortality in rural communities in Malawi: a population-based birth."— Presentation transcript:

1 Impact of monovalent rotavirus vaccine on diarrhoea-associated post-neonatal infant mortality in rural communities in Malawi: a population-based birth cohort study  Naor Bar-Zeev, PhD, Carina King, PhD, Tambosi Phiri, MSc, James Beard, MSc, Hazzie Mvula, MSc, Prof Amelia C Crampin, PhD, Ellen Heinsbroek, PhD, Sonia Lewycka, PhD, Jacqueline E Tate, PhD, Umesh D Parashar, MPH, Prof Anthony Costello, FMedSci, Charles Mwansambo, FRCPCH, Prof Robert S Heyderman, PhD, Neil French, PhD, Nigel A Cunliffe, PhD Osamu Nakagomi, Jennifer R Verani, Cynthia G Whitney Naor Bar-Zeev, PhD, Carina King, PhD, Tambosi Phiri, MSc, James Beard, MSc, Hazzie Mvula, MSc, Prof Amelia C Crampin, PhD, Ellen Heinsbroek, PhD, Sonia Lewycka, PhD, Jacqueline E Tate, PhD, Umesh D Parashar, MPH, Prof Anthony Costello, FMedSci, Charles Mwansambo, FRCPCH, Prof Robert S Heyderman, PhD, Neil French, PhD, Nigel A Cunliffe, PhD Osamu Nakagomi, Jennifer R Verani, Cynthia G Whitney  The Lancet Global Health  Volume 6, Issue 9, Pages e1036-e1044 (September 2018) DOI: /S X(18) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

2 Figure 1 STROBE study profile of the participating vaccine-eligible cohort, Site 1 *Completion of follow-up means sufficient information was obtained by 1 year of age to determine whether the participant could be included in analysis or excluded for the reasons outlined in the figure. The Lancet Global Health 2018 6, e1036-e1044DOI: ( /S X(18) ) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

3 Figure 2 12-month weighted moving average smoothed trend* for all-cause and diarrhoea-associated mortality and dose 3 pneumococcal and dose 2 rotavirus vaccine coverage in 10–51-week old infants (A) Site 1; January, 2012, to June, (B) Site 2; January, 2004, to June, RV1=monovalent rotavirus vaccine. PCV=pneumococcal conjugate vaccine. WASH=water and sanitation. *See appendix. The Lancet Global Health 2018 6, e1036-e1044DOI: ( /S X(18) ) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

4 Figure 3 Survival analysis of diarrhoea-associated death in the vaccine-eligible cohort, site 1 (A) Kaplan-Meier survival curve and 95% CIs, by vaccine receipt. (B) Fully parametric hazard rate over survival time, by vaccine receipt. (C) Vaccine effectiveness over survival time. (D) Hazard rate difference and 95% CIs (between vaccinated and unvaccinated infants) over survival time. RV=rotavirus vaccine. *Number at risk is the total number of surviving infants and infants who died with diarrhoea. 15 zero-dose and 209 two-dose recipients contributed to survival time until censoring for reasons other than death. The Lancet Global Health 2018 6, e1036-e1044DOI: ( /S X(18) ) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

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