1. Volume 67, Issue 1, Pages 14-33 (January 2005)
Polymorphism of host response genes: Implications in the pathogenesis and treatment of acute renal failure 
Bertrand L. Jaber, Brian J.G. Pereira, Joseph V. Bonventre, Vaidyanathapuram S. Balakrishnan, M.D. 
Kidney International 
Volume 67, Issue 1, Pages (January 2005)
DOI: /j x
Copyright © 2005 International Society of Nephrology Terms and Conditions

2. Figure 1
Structure of a human gene, sites of polymorphism, and functional relevance.
(Modified from205; reprinted with permission. Jaber BL et al: Blood Purif 22: 101–111, 2004).
Kidney International  , 14-33DOI: ( /j x)
Copyright © 2005 International Society of Nephrology Terms and Conditions

3. Figure 2
Types of gene polymorphism. (A) Single nucleotide polymorphism. (B) Variable number of tandem repeats or minisatellite loci polymorphism (DNA sequence 10 to 100bp in length). (C) Microsatellite loci polymorphism (DNA sequence of repeating units of 2 to 4 nucleotides).
Kidney International  , 14-33DOI: ( /j x)
Copyright © 2005 International Society of Nephrology Terms and Conditions

4. Figure 3
Schematic representation of the inflammatory response to sepsis and resulting kidney injury. Abbreviations are: GFR, glomerular filtration rate; NAG, N-acetyl-β-D-glucosaminidase; KIM, kidney injury molecule 1.
(Modified from205; reprinted with permission. Jaber BL et al: Blood Purif 22: 101–111, 2004).
Kidney International  , 14-33DOI: ( /j x)
Copyright © 2005 International Society of Nephrology Terms and Conditions

5. Figure 4
Key pathways involved in the generation and degradation of oxidants in acute renal failure. Abbreviations are: O2–, superoxide anion; SOD, superoxide dismutase; MPO, myeloperoxidase; NO, nitric oxide; ONOO–, peroxynitrite. OH·, hydroxyl radical; GPX, glutathione peroxidase; HOCl, hypochlorous acid; iNOS, inducible nitric oxide synthase.
Kidney International  , 14-33DOI: ( /j x)
Copyright © 2005 International Society of Nephrology Terms and Conditions