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Preliminary Evidence of an Association Between a Functional Interleukin-6 Polymorphism and Fatigue and Sleep Disturbance in Oncology Patients and Their.

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Presentation on theme: "Preliminary Evidence of an Association Between a Functional Interleukin-6 Polymorphism and Fatigue and Sleep Disturbance in Oncology Patients and Their."— Presentation transcript:

1 Preliminary Evidence of an Association Between a Functional Interleukin-6 Polymorphism and Fatigue and Sleep Disturbance in Oncology Patients and Their Family Caregivers  Christine Miaskowski, RN, PhD, FAAN, Marylin Dodd, RN, PhD, FAAN, Kathryn Lee, RN, PhD, Claudia West, RN, MS, Steven M. Paul, PhD, Bruce A. Cooper, PhD, William Wara, MD, Patrick S. Swift, MD, Laura B. Dunn, MD, Bradley E. Aouizerat, PhD  Journal of Pain and Symptom Management  Volume 40, Issue 4, Pages (October 2010) DOI: /j.jpainsymman Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

2 Fig. 1 Differences in mean a) evening and b) morning fatigue scores and c) sleep disturbance scores between common allele homozygotes (AA) compared with minor allele carriers (AT/TT) for the IL-6 c A>T polymorphism. All values are plotted as means±SDs. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

3 Fig. 2 Influence of a) age, b) gender, and c) genotype on interindividual differences in the intercept for evening fatigue, and d) the influence of baseline level of evening fatigue on the slope parameters for evening fatigue. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

4 Fig. 3 Influence of a) age and b) genotype on interindividual differences in the intercept for morning fatigue, and c) the influence of baseline level of morning fatigue on the slope parameters for morning fatigue. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

5 Fig. 4 Influence of a) age and b) genotype on interindividual differences in the intercept for sleep disturbance, and c) the influence of baseline level of sleep disturbance on the slope parameter for sleep disturbance. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © 2010 U.S. Cancer Pain Relief Committee Terms and Conditions

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