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Heterogeneity of hemochromatosis in Italy

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Presentation on theme: "Heterogeneity of hemochromatosis in Italy"— Presentation transcript:

1 Heterogeneity of hemochromatosis in Italy
Alberto Piperno*, Maurizio Sampietro‡, Antonello Pietrangelo§, Cristina Arosio*,∥, Loredana Lupica‡, Giuliana Montosi§, Anna Vergani*, Mirella Fraquelli¶, Domenico Girelli#, Paolo Pasquero**, Antonella Roetto**, Paolo Gasparini‡‡, Silvia Fargion‡, Dario Conte¶, Clara Camaschella**  Gastroenterology  Volume 114, Issue 5, Pages (May 1998) DOI: /S (98) Copyright © 1998 American Gastroenterological Association Terms and Conditions

2 Fig. 1 Frequency of HFE genotypes in Italian patients with a hemochromatosis phenotype divided according to geographical origin (ascertained up to the third generation). C282Y +/+ genotype: P < between patients of northern and central/southern Italy. Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions

3 Fig. 2 Distribution of C282Y homozygotes according to ancestral haplotype combinations and phenotype severity (based on the ratio of total IR and age [IR/age]. Class I includes patients with IR/age ≤ Class II includes patients with IR/age > 0.33. Gastroenterology  , DOI: ( /S (98) ) Copyright © 1998 American Gastroenterological Association Terms and Conditions


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