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Mast cell activation syndrome: Proposed diagnostic criteria

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1 Mast cell activation syndrome: Proposed diagnostic criteria
Cem Akin, MD, PhD, Peter Valent, MD, Dean D. Metcalfe, MD  Journal of Allergy and Clinical Immunology  Volume 126, Issue 6, Pages e4 (December 2010) DOI: /j.jaci Copyright © Terms and Conditions

2 Fig 1 Bone marrow findings in patients with mast cell activation disorders. A, Tryptase-stained bone marrow sections revealed diffusely scattered spindle-shaped mast cells that did not form compact aggregates. B, Small-sized multifocal aggregates of mast cells were found, some of which contained 15 or more mast cells. Mast cells expressed CD25. Findings in Fig 1, A, are consistent with the diagnosis of an MMAS, whereas findings in Fig 1, B, are consistent with the diagnosis of systemic mastocytosis. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © Terms and Conditions

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