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Variable versus conventional lung protective mechanical ventilation during open abdominal surgery (PROVAR): a randomised controlled trial P.M. Spieth, A. Güldner, C. Uhlig, T. Bluth, T. Kiss, C. Conrad, K. Bischlager, A. Braune, R. Huhle, A. Insorsi, F. Tarantino, L. Ball, M.J. Schultz, N. Abolmaali, T. Koch, P. Pelosi, M. Gama de Abreu British Journal of Anaesthesia Volume 120, Issue 3, Pages (March 2018) DOI: /j.bja Copyright © 2017 British Journal of Anaesthesia Terms and Conditions
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Fig 1 CONSORT Diagram. Patient flow in the PROtective VARiable ventilation (PROVAR) study according to the CONSORT guidelines. 188 patients were screened for eligibility and 50 were finally enrolled in the trial. 25 patients were randomly assigned to receive either controlled variable ventilation or controlled non-variable ventilation, respectively. One patient in CVV and CNV groups refused being submitted to further measurements after days 1 and 3, respectively. One patient in CNV group was still intubated at day 1, so that the primary endpoint could not be assessed. Therefore intention to treat (ITT) analysis was performed in 24 patients in CVV and 23 patients in CNV group, respectively. British Journal of Anaesthesia , DOI: ( /j.bja ) Copyright © 2017 British Journal of Anaesthesia Terms and Conditions
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Fig 2 Forced vital capacity as percent of expected normal value. Closed circles represent controlled non-variable ventilation (CNV), whereas open circles represent controlled variable ventilation (CVV). Red lines represent mean and standard deviation. General linear model statistics were used to assess group, time and group∗time effects. A P < 0.05 was considered statistically significant. British Journal of Anaesthesia , DOI: ( /j.bja ) Copyright © 2017 British Journal of Anaesthesia Terms and Conditions
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