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Brain imaging research

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Presentation on theme: "Brain imaging research"— Presentation transcript:

1 Brain imaging research

2 Features of all methods
PET excellent spatial resolution fMRI poor temporal resolution EEG poor spatial resolution MEG excellent temporal resolution

3 Features of all methods
Meyer-Lindernberg, A. From maps to mechanisms through neuroimaging of schizophrenia. Nature, 468:

4 odour taste WORD tactile tone Basic introduction to ERPs
ERP … event-related potential result of processed raw EEG signal (electroencephalography) The event represents a controlled independent variable The potential represents the measured dependent variable odour taste WORD tactile tone stimulus

5 An actual ERP

6 0ms 0ms 0ms 0ms

7 Rohes Signal gefiltert Gemitteltes Signal gefiltert 0ms 0ms 1000ms 1000ms

8 Gemittelte Signale gefiltert 1000ms 0ms

9 Basic EEG introduction
EEG measures voltage fluctuations resulting from ionic current flows within the neurons of the brain Hans Berger • first human EEG in 1924 • invented the electroencephalogram Brain potentials from his 16 year old son Klaus

10 More history 1934/35: Confirmation by the labs of Adrian, Jasper, and Davis 1939: Single-trial ERPs reported by Pauline & Hallowell Davis : Sensory ERPs recorded with primitive methods 1962: First publication of computer-averaged ERPs by Galambos © S. J. Luck. All Rights Reserved. May be used for nonprofit educational purposes if this copyright notice is included. Permission must be obtained from the copyright holder(s) for any other use.

11 Basics of Neurophysiology (where does an EEG signal come from?)
Magnification for microscopic vision Portion of Figure 5.2 reprinted from Luck, S. J., & Girelli, M. (1998). Electrophysiological approaches to the study of selective attention in the human brain. In R. Parasuraman (Ed.), The Attentive Brain (pp ). Cambridge, MA: MIT Press. © MIT Press. This material may be used for nonprofit research and education purposes only, and it may not be reprinted or distributed in any form including print and electronic forms. Other content: © S. J. Luck. All Rights Reserved. May be used for nonprofit educational purposes if this copyright notice is included. Permission must be obtained from the copyright holder(s) for any other use.

12 Basics of Neurophysiology (where does an EEG signal come from?)
Portion of Figure 5.2 reprinted from Luck, S. J., & Girelli, M. (1998). Electrophysiological approaches to the study of selective attention in the human brain. In R. Parasuraman (Ed.), The Attentive Brain (pp ). Cambridge, MA: MIT Press. © MIT Press. This material may be used for nonprofit research and education purposes only, and it may not be reprinted or distributed in any form including print and electronic forms. Other content: © S. J. Luck. All Rights Reserved. May be used for nonprofit educational purposes if this copyright notice is included. Permission must be obtained from the copyright holder(s) for any other use.

13 Different faces of EEG

14 Other methods to record brain activity
Positron Emission Tomography (PET) Functional Magnet Resonance Imaging (fMRI) Magnetoencephalography (MEG)


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