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Abnormal Epidermal Barrier Recovery in Uninvolved Skin Supports the Notion of an Epidermal Pathogenesis of Psoriasis  Li Ye, Chengzhi Lv, George Man,

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Presentation on theme: "Abnormal Epidermal Barrier Recovery in Uninvolved Skin Supports the Notion of an Epidermal Pathogenesis of Psoriasis  Li Ye, Chengzhi Lv, George Man,"— Presentation transcript:

1 Abnormal Epidermal Barrier Recovery in Uninvolved Skin Supports the Notion of an Epidermal Pathogenesis of Psoriasis  Li Ye, Chengzhi Lv, George Man, Shunpeng Song, Peter M. Elias, Mao-Qiang Man  Journal of Investigative Dermatology  Volume 134, Issue 11, Pages (November 2014) DOI: /jid Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Comparison of stratum corneum (SC) biophysical properties among normal, involved, and uninvolved psoriatic skin sites. (a, b) Depict basal TEWL and barrier recovery rates, respectively. (c, d) Present skin surface pH and SC hydration, respectively. Results are expressed as mean±SEM in comparison with normal skin, as shown by the horizontal dotted lines. GraphPad Prism 4 software (GraphPad Software, La Jolla, CA) was used for all statistical analysis. Dunnett's multiple-comparison test was used to determine the difference between normal and psoriasis-involved and -uninvolved skin, except in Figure 1b in which the differences between normal and progressive uninvolved skin were determined with the unpaired t-test. P<0.05 was considered to be a statistically significant difference. Significant differences are shown in the figures, and the numbers of subjects are detailed in Table 1. Progressive in, progressive involved; Progressive unin, progressive uninvolved; Stable in, stable involved; Stable unin, stable uninvolved; TEWL, transepidermal water loss. Journal of Investigative Dermatology  , DOI: ( /jid ) Copyright © 2014 The Society for Investigative Dermatology, Inc Terms and Conditions


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