1. Volume 92, Issue 4, Pages 953-963 (October 2017)
Elevated factor H–related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy 
Agustín Tortajada, Eduardo Gutiérrez, Elena Goicoechea de Jorge, Jaouad Anter, Alfons Segarra, Mario Espinosa, Miquel Blasco, Elena Roman, Helena Marco, Luis F. Quintana, Josué Gutiérrez, Sheila Pinto, Margarita Lopez-Trascasa, Manuel Praga, Santiago Rodriguez de Córdoba 
Kidney International 
Volume 92, Issue 4, Pages (October 2017)
DOI: /j.kint
Copyright © 2017 International Society of Nephrology Terms and Conditions

2. Figure 1
ΔCFHR3-CFHR1 association with IgA nephropathy (IgAN) in the Spanish population. (a) The number and proportion of IgAN, autosomal dominant polycystic kidney disease (ADPKD), and control individuals having each of the 3 ΔCFHR3-CFHR1 genotypes. (b) Comparison of the frequencies of the ΔCFHR3-CFHR1 allele in IgAN and ADPKD patients and control individuals. 95% CI, confidence interval; Freq., frequency; Het., ΔCFHR3-CFHR1 heterozygotes; Hom., ΔCFHR3-CFHR1 homozygotes; No, non-carriers of ΔCFHR3-CFHR1; OR, odds ratio.
Kidney International  , DOI: ( /j.kint )
Copyright © 2017 International Society of Nephrology Terms and Conditions

3. Figure 2
Factor H-related protein 1 (FHR-1) levels and FHR-1:factor H (FH) ratio are increased in Spanish IgA nephropathy (IgAN) and autosomal dominant polycystic kidney disease (ADPKD) patients. Comparison of FH levels (a), FHR-1 levels (b), and FHR-1:FH ratios (c) among IgAN patients, ADPKD patients, and control individuals (CTR) [right, non-carriers of ΔCFHR3-CFHR1 (No ΔCFHR3-CFHR1); left, ΔCFHR3-CFHR1 heterozygotes (Het ΔCFHR3-CFHR1)]. Each symbol represents an individual. Mean values and SD are indicated with lines. P values for significant comparisons are summarized in Table 2. ns, not significant.
Kidney International  , DOI: ( /j.kint )
Copyright © 2017 International Society of Nephrology Terms and Conditions

4. Figure 3
Increased factor H-related protein 1 (FHR-1) levels and FHR-1:factor H (FH) ratio are associated with decreased renal function in Spanish IgA nephropathy (IgAN) and autosomal dominant polycystic kidney disease (ADPKD) patients. Comparison of FH levels (a), FHR-1 levels (b), and FHR-1:FH ratios (c) among control individuals (CTR), progressive (Prog.) and nonprogressive (No Prog.) IgAN patients, and ADPKD patients with and without chronic kidney disease (left, IgAN patients; right, ADPKD patients). Data for only non-carriers of the ΔCFHR3-CFHR1 allele are shown. ΔCFHR3-CFHR1 heterozygotes are shown in Supplementary Figure S2. Each symbol represents an individual. Mean values and SD are indicated with lines. P values for significant comparisons are indicated at the top of each graph. ns, not significant.
Kidney International  , DOI: ( /j.kint )
Copyright © 2017 International Society of Nephrology Terms and Conditions

5. Figure 4
IgA nephropathy (IgAN) patients with CFH pathogenic variants. The pedigrees of IgAN patients with CFH pathogenic variants are shown. Below each pedigree is a comparison of the patient’s CFH DNA sequences with a normal CFH DNA sequence. Four IgAN patients, namely IgAN-013 (a), IgAN-046 (b), IgAN-072 (c), and IgAN-217 (d), showed CFH heterozygote mutations. For each individual, the factor H (FH) and factor H-related protein 1 (FHR-1) levels and the FHR-1:FH ratio are indicated. Abnormal levels are depicted in bold. Affected individuals are indicated with solid symbols. Individuals with CFH mutations are labeled with a solid dot that indicates the specific CFH mutation. A clinical synopsis for each of these patients is provided as Supplementary Material.
Kidney International  , DOI: ( /j.kint )
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