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Maternal immunisation with trivalent inactivated influenza vaccine for prevention of influenza in infants in Mali: a prospective, active-controlled, observer-blind,

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Presentation on theme: "Maternal immunisation with trivalent inactivated influenza vaccine for prevention of influenza in infants in Mali: a prospective, active-controlled, observer-blind,"— Presentation transcript:

1 Maternal immunisation with trivalent inactivated influenza vaccine for prevention of influenza in infants in Mali: a prospective, active-controlled, observer-blind, randomised phase 4 trial  Milagritos D Tapia, MD, Prof Samba O Sow, MD, Boubou Tamboura, PharmD, Ibrahima Tégueté, MD, Prof Marcela F Pasetti, PhD, Mamoudou Kodio, PharmD, Uma Onwuchekwa, BS, Sharon M Tennant, PhD, Prof William C Blackwelder, PhD, Flanon Coulibaly, MD, Awa Traoré, PharmD, Adama Mamby Keita, MD, Fadima Cheick Haidara, MD, Fatoumata Diallo, MD, Moussa Doumbia, MD, Doh Sanogo, MD, Ellen DeMatt, MA, Nicholas H Schluterman, PhD, Andrea Buchwald, BS, Prof Karen L Kotloff, MD, Wilbur H Chen, MD, Evan W Orenstein, MD, Lauren A V Orenstein, MD, Julie Villanueva, PhD, Joseph Bresee, MD, Prof John Treanor, MD, Prof Myron M Levine, MD  The Lancet Infectious Diseases  Volume 16, Issue 9, Pages (September 2016) DOI: /S (16) Copyright © 2016 Tapia et al. Open Access article distributed under the terms of CC BY Terms and Conditions

2 Figure 1 Trial profile TIIV=trivalent inactivated influenza vaccine. MCV=quadrivalent meningococcal conjugate vaccine. *1886 (91%) infants were born to women vaccinated with TIIV 14 or more days prepartum. †1869 (92%) infants were born to women vaccinated with MCV 14 or more days prepartum. The Lancet Infectious Diseases  , DOI: ( /S (16) ) Copyright © 2016 Tapia et al. Open Access article distributed under the terms of CC BY Terms and Conditions

3 Figure 2 Vaccine efficacy and HAI antibody geometric mean titres in infants, by age and maternal vaccine group Error bars and data in parentheses show 95% CIs. TIIV=trivalent inactivated influenza vaccine. MCV=quadrivalent meningococcal conjugate vaccine. HAI=hemagglutination inhibition antibodies. The Lancet Infectious Diseases  , DOI: ( /S (16) ) Copyright © 2016 Tapia et al. Open Access article distributed under the terms of CC BY Terms and Conditions


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