1. Aneuploidy is a key causal factor of delays in blastulation: author response to ‘A cautionary note against aneuploidy risk assessment using time-lapse imaging’ 
Alison Campbell, Simon Fishel, Mette Laegdsmand 
Reproductive BioMedicine Online 
Volume 28, Issue 3, Pages (March 2014)
DOI: /j.rbmo
Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

2. Figure 1
The time to start of blastulation (A, n=1517) and to full blastocyst (B, n=1271) in hours versus the age in years of the patients at the time of autologous oocyte retrieval. The black line is the trend (linear regression) line, the blue lines indicate the 95% confidence interval and the green lines indicate the 95% prediction interval. hpi=hours post insemination; tB=time from insemination to a full blastocoele where the blastocysts has not yet started expansion; tSB=time from insemination to start of blastulation. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
Reproductive BioMedicine Online  , DOI: ( /j.rbmo )
Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions

3. Figure 2
Three classes of aneuploidy risk (low, medium and high) based on time from insemination to a full blastocoele where the blastocysts has not yet started expansion (tB) and time from insemination to start of blastulation (tSB) with revised limits. Data are divided into patient age at the time of oocyte retrieval – <40 (A) and ⩾40years (B) – demonstrating how the risk classification model is effectively applied for patients in these two different age categories. hpi=hours post insemination.
Reproductive BioMedicine Online  , DOI: ( /j.rbmo )
Copyright © 2013 Reproductive Healthcare Ltd. Terms and Conditions