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Reduced protease inhibitory capacity in patients with abdominal aortic aneurysms is reversed with surgical repair  Vivienne J. Halpern, MD, Mahesh Mathrumbutham,

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Presentation on theme: "Reduced protease inhibitory capacity in patients with abdominal aortic aneurysms is reversed with surgical repair  Vivienne J. Halpern, MD, Mahesh Mathrumbutham,"— Presentation transcript:

1 Reduced protease inhibitory capacity in patients with abdominal aortic aneurysms is reversed with surgical repair  Vivienne J. Halpern, MD, Mahesh Mathrumbutham, PhD, Christopher LaGraize, MD, Srinvasa K. Rao, PhD, Glenn R. Faust, MD, Jon R. Cohen, MD  Journal of Vascular Surgery  Volume 35, Issue 4, Pages (April 2002) DOI: /mva Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

2 Fig. 1 The effect of open surgical repair of AAA on elastolytic activity. After open surgical repair, the increased elastolytic activity seen in AAA patients returns to that of controls. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

3 Fig. 2 Assay for protease activity, which can be applied to many substrate-enzyme combinations. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

4 Fig. 3 The AAA patients have a statistically significant reduction in plasma inhibitory capacity as compared with that of controls (P <.001) Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

5 Fig. 4 The effect of smoking on inhibitory capacity. There is a statistically significant difference between controls and AAA both in patients who smoke and those who do not (P <.01). There is no statistical difference between smokers and nonsmokers in patients with AAA or in the control group. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

6 Fig. 5 The effect of AAA size on inhibitory capacity. Control versus the 3 to 4.9 cm group and the 5 to 6.9 cm group both have statistically significant differences (P <.05). The 3 to 4.9 cm group compared with the 5 to 6.9 cm group have statistically significant differences (P <.05). The >7 cm group was not significantly different from that of control. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

7 Fig. 6 The effect of open surgical repair on plasma inhibitory capacity. After open surgical repair, postoperative inhibitory capacity is significantly increased as compared with preoperative levels (P <.001). The postoperative level is not significantly different from that of controls. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

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