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Volume 63, Issue 5, Pages 1708-1713 (May 2003)
Cardiomyocyte loss in experimental renal failure: Prevention by ramipril Kerstin Amann, Karin Tyralla, Marie-Luise Gross, Ute Schwarz, Johannes Törnig, Christian Stefan Haas, Eberhard Ritz, Gerhard Mall Kidney International Volume 63, Issue 5, Pages (May 2003) DOI: /j x Copyright © 2003 International Society of Nephrology Terms and Conditions
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Figure 1 Myocyte apoptosis and activation in renal failure. Increased number of apoptotic myocardial cells by terminal deoxynucleotidyl transferase-mediated uridine triphosphate nick end labeling (TUNEL) staining in untreated subtotal nephrectomy (SNX) rats (A) compared to controls (B). Increased number of proliferating cellular nuclear antigen (PCNA)-positive cardiomyocytes (red nuclear staining) in SNX rats (C) compared to sham-operated controls (D). Please note also marked hypertrophy of cardiomyocytes, as well as interstitial cell activation (arrow) in SNX (C) compared to sham-operated control rats (D). Paraffin sections, magnification × 40. Kidney International , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions
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