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FOXO in the Hole: Leveraging GWAS for Outcome and Function

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Presentation on theme: "FOXO in the Hole: Leveraging GWAS for Outcome and Function"— Presentation transcript:

1 FOXO in the Hole: Leveraging GWAS for Outcome and Function
Peter K. Gregersen, Nataly Manjarrez-Orduño  Cell  Volume 155, Issue 1, Pages (September 2013) DOI: /j.cell Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 The Identification of FOXO3 as a Marker of Disease Outcomes
An integrative analytic approach that utilizes data from GWAS and clinical outcomes along with work in human monocytes and mouse models has revealed that differences in FOXO3 levels alter the balance of proinflammatory (TNF) versus anti-inflammatory (IL10) cytokine production. This influences the outcome of various diseases that are either exacerbated or ameliorated by these inflammatory responses. Cell  , 11-12DOI: ( /j.cell ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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