1. Gadolinium Update

3. Gadolinium-Based Contrast Agents Background

4. Gadolinium-Based Contrast Agents Background (cont)

5. Basic Structures of Commercially Available GBCAs

6. GBCAs and NSF

7. 2018 ACR Manual, Version 10.3

8. Risk Factors for CKD

9. Gadolinium Use in Renal Impairment ACR and FDA Guidelines

10. NSF Key Takeaways

11. GBCA Deposition and Retention in the Brain Background

12. GBCAs Retention or Deposition?

13. Are There Clinical Correlates?

14. GBCA Deposition and Retention FDA Response

15. Intracranial GBCA Deposition and Retention EMA Response

16. Summary What is Known About Gd Deposition and Retention?

17. GBCA Use During Pregnancy

18. GBCA-Enhanced MRI for Breast Cancer Screening

19. GBCA Use in Pediatric Populations

20. Concluding Remarks

21. Abbreviations