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Covering the Cover Gastroenterology

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1 Covering the Cover Gastroenterology
Andrew T. Chan, Christopher S. Williams  Gastroenterology  Volume 151, Issue 5, Pages (November 2016) DOI: /j.gastro Copyright © 2016 AGA Institute Terms and Conditions

2 Figure 1 The number of LVLs per endoscopic view was counted, and the grading was divided into the following 3 categories: (Group A) grade A, no lesions; (Group B) grade B, 1-9 lesions; and (Group C) grade C, 10 or more lesions. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions

3 Figure 2 Cumulative incidence of metachronous squamous cell carcinomas (SCCs) according to the LVL grade in esophagus and head and neck region. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions

4 Figure 3 Proposed model of metalloproteinases-1 (TIMP-1)–induced hepatic stellate cell (HSC)-mediated premetastatic niche formation. Early induced TIMP-1 in the course of pancreatic ductal adenocarcinoma (PDAC) development activates HSCs via its receptor CD63 and subsequent PI3K activation. TIMP-1–activated HSCs express stromal cell–derived factor (SDF)-1 and recruit neutrophils thereby mediating pre-metastatic niche formation and metastasis. Asterisks indicate crucial components of the proposed pathway. aHSC, activated HSC; qHSC, quiescent HSC. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2016 AGA Institute Terms and Conditions


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