Presentation is loading. Please wait.

Presentation is loading. Please wait.

Mechanisms of Age-Related Macular Degeneration

Published byGabriel Henrique Rocha Modified over 5 years ago

Similar presentations

Presentation on theme: "Mechanisms of Age-Related Macular Degeneration"— Presentation transcript:

1 Mechanisms of Age-Related Macular Degeneration
Jayakrishna Ambati, Benjamin J. Fowler  Neuron  Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Fundus Photographs in Health and in AMD
(A) The ocular fundus of a healthy eye, showing normal pigmentation and retinal blood vessels. (B) The late-stage dry form of AMD, known as geographic atrophy. Note large regions of depigmentation, especially in the macula, which is at the center of the image. (C) In wet AMD, leaky blood vessels from the choroid invade the overlying retina. Neuron  , 26-39DOI: ( /j.neuron ) Copyright © 2012 Elsevier Inc. Terms and Conditions

3 Figure 2 The Immunovascular Axis of Wet AMD
There are numerous overlapping proangiogenic mechanisms that underlie wet AMD, many of which involve the intersection of immune and vascular systems. See corresponding text in Review. Neuron  , 26-39DOI: ( /j.neuron ) Copyright © 2012 Elsevier Inc. Terms and Conditions

4 Figure 3 Toxic Accumulations in Dry AMD
Left: dry AMD is characterized by the accumulation of various types of retinal debris. Right: the interplay of reactive oxygen species and autophagy in disease pathogenesis is an emerging theme in AMD and other common neurodegenerations. See corresponding text in Review. Neuron  , 26-39DOI: ( /j.neuron ) Copyright © 2012 Elsevier Inc. Terms and Conditions

5 Figure 4 DICER1: Central Hub of the RPE
The miRNA-processing enzyme DICER1 is a key determinant of RPE cell health. Several noncanonical (miRNA-independent) roles for DICER1 have been described in AMD, including regulation of inflammation and cytotoxic noncoding Alu RNAs. See corresponding text in Review. Neuron  , 26-39DOI: ( /j.neuron ) Copyright © 2012 Elsevier Inc. Terms and Conditions

Download ppt "Mechanisms of Age-Related Macular Degeneration"

Similar presentations

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages 733-745 (September 2009) DOI:

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:
Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.
Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.
Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages 12-24 (July 2010) DOI: 10.1016/j.immuni.2010.07.006.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni
Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.
The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages 844-866 (November 2013) DOI: 10.1016/j.neuron.2013.10.008 Copyright.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.
DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,
Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages 791-806 (October 2013) DOI: 10.1016/j.neuron.2013.10.047.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages 38-52 (April 2008) DOI: 10.1016/j.cell.2008.03.011.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages 951-962 (June 2006) DOI: 10.1016/j.neuron.2006.04.035.

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron
Rpe65 Is the Retinoid Isomerase in Bovine Retinal Pigment Epithelium Minghao Jin, Songhua Li, Walid N. Moghrabi, Hui Sun, Gabriel H. Travis Cell Volume.

Rpe65 Is the Retinoid Isomerase in Bovine Retinal Pigment Epithelium Minghao Jin, Songhua Li, Walid N. Moghrabi, Hui Sun, Gabriel H. Travis Cell Volume.
Auditory Hair Cell-Afferent Fiber Synapses Are Specialized to Operate at Their Best Frequencies M.E. Schnee, D.M. Lawton, D.N. Furness, T.A. Benke, A.J.

Auditory Hair Cell-Afferent Fiber Synapses Are Specialized to Operate at Their Best Frequencies M.E. Schnee, D.M. Lawton, D.N. Furness, T.A. Benke, A.J.
Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages 1262-1272 (September 2014)

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)
Multiscale Optical Ca2+ Imaging of Tonal Organization in Mouse Auditory Cortex John B. Issa, Benjamin D. Haeffele, Amit Agarwal, Dwight E. Bergles, Eric.

Multiscale Optical Ca2+ Imaging of Tonal Organization in Mouse Auditory Cortex John B. Issa, Benjamin D. Haeffele, Amit Agarwal, Dwight E. Bergles, Eric.
Normal Movement Selectivity in Autism Ilan Dinstein, Cibu Thomas, Kate Humphreys, Nancy Minshew, Marlene Behrmann, David J. Heeger Neuron Volume 66, Issue.

Normal Movement Selectivity in Autism Ilan Dinstein, Cibu Thomas, Kate Humphreys, Nancy Minshew, Marlene Behrmann, David J. Heeger Neuron Volume 66, Issue.
Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.
Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.

Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.
Independent Genomic Control of Neuronal Number across Retinal Cell Types Patrick W. Keeley, Irene E. Whitney, Nils R. Madsen, Ace J. St. John, Sarra Borhanian,

Independent Genomic Control of Neuronal Number across Retinal Cell Types Patrick W. Keeley, Irene E. Whitney, Nils R. Madsen, Ace J. St. John, Sarra Borhanian,
Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.
Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages 333-338 (February 2008) DOI: 10.1016/j.neuron.2008.01.018.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

Similar presentations

Ads by Google