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New Clinical Insights Into the Pathology of Amyloidosis

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Presentation on theme: "New Clinical Insights Into the Pathology of Amyloidosis"— Presentation transcript:

1 New Clinical Insights Into the Pathology of Amyloidosis

2 What is Amyloidosis?

3 Protein Structure A Brief Review

4 What Makes a Protein Amyloidogenic?

5 Amyloidoses Protein Folding Disorders

6 Amyloidoses Protein Folding Disorders

7 What Are Amyloidoses?

8 AL (Amyloid Light Chain)

9 External Signs of AL Amyloidosis

10 Hereditary Transthyretin Amyloidosis

11 Hereditary Transthyretin Amyloidosis

12 Wild-Type ATTR

13 AA Amyloidosis

14 ALECT2 Amyloidosis

15 Diagnosis of Amyloidosis

16 Diagnosis of Amyloidosis (cont)

17 Clinical Suspicion of Amyloidosis

18 Fine Needle Abdominal Fat Pad Biopsies

19 Sensitivity of Various Organ Biopsies in the Diagnosis of Amyloidosis

20 Diagnostic Algorithm for Systemic Amyloidoses

21 Key Points to Consider for Amyloid Protein Typing

22 Amyloid Protein Typing Challenges With Immunohistochemistry

23 Proteomic Analysis to Classify Amyloidoses

24 Genetic Testing

25 Determining an Appropriate Treatment Plan

26 Therapies in AL amyloidosis Targeting the Precursor Protein

27 Therapies in AA and ALECT2 Amyloidosis

28 Hereditary Transthyretin Amyloidosis Current Approaches

29 Concluding Remarks

30 Abbreviations


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