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Challenging Lung Carcinoma with Coexistent ΔNp63/p40 and Thyroid Transcription Factor-1 Labeling Within the Same Individual Tumor Cells  Giuseppe Pelosi,

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Presentation on theme: "Challenging Lung Carcinoma with Coexistent ΔNp63/p40 and Thyroid Transcription Factor-1 Labeling Within the Same Individual Tumor Cells  Giuseppe Pelosi,"— Presentation transcript:

1 Challenging Lung Carcinoma with Coexistent ΔNp63/p40 and Thyroid Transcription Factor-1 Labeling Within the Same Individual Tumor Cells  Giuseppe Pelosi, MD, MIAC, Alessandra Fabbri, MD, Elena Tamborini, DSc, Federica Perrone, DSc, Adele M. Testi, DSc, Giulio Settanni, DSc, Adele Busico, DSc, Giovanni Centonze, LabTech, Paola Braidotti, DSc, Gaetano Bulfamante, MD, Filippo De Braud, MD, Marina Garassino, MD, Ugo Pastorino, MD  Journal of Thoracic Oncology  Volume 10, Issue 10, Pages (October 2015) DOI: /JTO Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Biopsy tissue fragments showing poorly differentiated non–small-cell lung carcinoma (NSCLC) (A,B) with focal features suggestive of squamous cell differentiation (B, insets). Upon immunohistochemistry, a widespread and strong nuclear decoration was seen for both p40 (C, inset) and thyroid transcription factor-1 (TTF1) (D, inset), supporting a biphenotypic tumor at the level of the same individual tumor cells. Electron microscopy confirmed this dual concurrent differentiation at the level of the same individual cells showing (E) tumor cells partly lining lumen spaces with cytoplasm extensions (arrowhead), numerous mucous granules (asterisks) and abundant electron-dense thick tonofilaments around the nucleus (arrows), and (F) tumor cells with adjacent lumen (arrowhead) and bundles of electron-dense tonofilaments (arrows). Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Mutations of KRAS (AAA>AAT, K117N, exon 4, 32% allelic DNA) (A) and TP53 (GTG>GGG, V272G, exon 8, 71% allelic DNA) (B) gene are shown as derived from targeted next generation sequencing, which are either typical of or frequent in lung adenocarcinoma. Tumor cells showed also concurrent FGFR1 gene amplification typical of squamous cell carcinoma, with an average copy number being 7.1 signals in all tumor cells (C, inset). Journal of Thoracic Oncology  , DOI: ( /JTO ) Copyright © 2015 International Association for the Study of Lung Cancer Terms and Conditions

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