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miR-214 as a Key Hub that Controls Cancer Networks: Small Player, Multiple Functions
Elisa Penna, Francesca Orso, Daniela Taverna Journal of Investigative Dermatology Volume 135, Issue 4, Pages (April 2015) DOI: /jid Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 1 Genomic location of human miR-214. miR-214 and miR-199a-2 are 6 kb apart, located inside the 7.9 kb-long noncoding RNA precursor, DNM3os, in intron 14 of the Dynamin-3 (DNM3) gene (1q24.3). miR-3120 overlaps the miR-214 locus but in its complementary strand. Journal of Investigative Dermatology , DOI: ( /jid ) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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Figure 2 miR-214 controls cancer networks. miR-214 direct target genes and indirect downstream players are shown, together with their multiple functions in tumor cells (different colors). Journal of Investigative Dermatology , DOI: ( /jid ) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions
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