1. Volume 49, Issue 2, Pages 234-236 (January 2013)
Comprehensive Mapping of DNA Damage: From Static Genetic Maps to Condition- Specific Maps 
Nir Friedman 
Molecular Cell 
Volume 49, Issue 2, Pages (January 2013)
DOI: /j.molcel
Copyright © 2013 Elsevier Inc. Terms and Conditions

2. Figure 1
Conceptualization of Differential Genetic Interaction Scores and Summary of the Experimental Design
(A) Illustration of genetic interaction. For each strain (wild-type, deletion of X, deletion of Y, and double deletion), we measure fitness. The expected fitness for the double deletion is compared to the actual fitness. If it is higher we say that the two genes have positive interaction and if it is lower that they have negative interaction (marked in yellow and blue, respectively).
(B) Left: A hypothetical network with three pathways, all contributing to growth. The third pathway (damage → D → E → growth) is relevant only when there is damage. Middle: Interaction maps under control and damage conditions, where edge color represents the sign of interaction and width the magnitude of interaction. Interactions between redundant pathways are negative and within a pathway are positive. Right: Differential network resulting from contrasting the two networks, where red denotes decreased (more negative) interaction and green increased interaction.
(C) Illustration of the experimental design taken by Guénolé et al.
(D) A network built by combining differential interactions. Two subnetworks are highlighted.
Panels (C) and (D) are adopted from Guénolé et al. (2013).
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2013 Elsevier Inc. Terms and Conditions