1. Nipple Angiofibromas with Loss of TSC2 Are Associated with Tuberous Sclerosis Complex 
Neera Nathan, Magdalena E. Tyburczy, Lana Hamieh, Ji-an Wang, G. Thomas Brown, Chyi-Chia Richard Lee, David J. Kwiatkowski, Joel Moss, Thomas N. Darling 
Journal of Investigative Dermatology 
Volume 136, Issue 2, Pages (February 2016)
DOI: /j.jid
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2. Figure 1
Gross and microscopic features of nipple-areolar complex angiofibromas. (a) Pink papules on the nipple and areola. (b) Hematoxylin and eosin stain shows increased number of dilated vessels and fibroblasts consistent with the diagnosis of an angiofibroma. (c) Factor XIIIa staining demonstrates positive cells in the dermis as seen in facial angiofibromas. (d) Immunoreactivity to phosphorylated ribosomal protein S6 in scattered dermal fibroblast-like cells suggests hyperactivation of the mechanistic target of rapamycin complex 1.
Journal of Investigative Dermatology  , DOI: ( /j.jid )
Copyright © 2015 The Authors Terms and Conditions