Presentation is loading. Please wait.

Presentation is loading. Please wait.

Brent E. Palmer, PhD, Douglas G. Mack, PhD, Allison K

Published by润 闻 Modified over 5 years ago

Similar presentations

Presentation on theme: "Brent E. Palmer, PhD, Douglas G. Mack, PhD, Allison K"— Presentation transcript:

1 CD57 expression correlates with alveolitis severity in subjects with beryllium-induced disease 
Brent E. Palmer, PhD, Douglas G. Mack, PhD, Allison K. Martin, MS, Lisa A. Maier, MD, Andrew P. Fontenot, MD  Journal of Allergy and Clinical Immunology  Volume 120, Issue 1, Pages (July 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 The distribution and frequency of beryllium-specific CD4+ T cells in blood and BAL from subjects with CBD. A, Representative example of intracellular cytokine staining on blood and BAL cells stimulated with medium, BeSO4 or SEB. B, The frequency of beryllium-specific (left) and SEB-reactive (right) CD4+ T cells from peripheral blood and BAL is shown. Solid lines represent the median values for each group. C, The proportion (mean ± SEM) of beryllium-specific (left) and SEB-reactive (right) CD4+ T cells within the different TH1-type cytokine-secreting T-cell populations from blood and BAL is depicted. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Expression of CD57 on blood and BAL CD4+ T cells. A, Representative example of CD57 staining on CD4+ T cells from blood and BAL of a patient with CBD is shown. B, The percentage of CD4+CD57+ T cells in blood of BeS, CBD, and normal control subjects and BAL of BeS, CBD, and sarcoidosis subjects is shown. Median values are indicated with solid lines. C, Correlation between the percentage of CD4+CD57+ T cells in the BAL and total BAL lymphocyte count. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Distribution of CD57 on memory T-cell populations in blood and BAL. A, Representative example of CD57 staining on CD4+ TCM, TEM, and TEMTD cells from blood is shown. B, The percentage of TCM, TEM, and TEMTD CD4+ T cells expressing CD57 on blood and BAL cells from patients with CBD (n = 12) is shown. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Distribution of CD57 on beryllium-specific, TH1-type cytokine-producing CD4+ T cells from subjects with CBD. Representative examples of CD57 expression on beryllium-specific, TH1-type cytokine-producing CD4+ T cells in blood (A) and BAL (B) are shown. The overall percentage of beryllium-specific (C) and SEB-reactive (D) TH1-type cytokine-secreting CD4+ T cells that express CD57 in blood and BAL is depicted. Solid lines represent the median values for each group. ND, Not detected. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Beryllium-specific CD4+CD57+ T cells from subjects with CBD exhibit reduced proliferative capacity. A, Representative density plots of CFSE-labeled PBMCs after 5 days of stimulation with medium (left), BeSO4 (middle), or αCD3 (right) are shown. B, The percentage of CD57+ and CD57− CFSElow CD4+ T cells from BeSO4-stimulated blood (left) and BAL (middle) and anti-CD3–stimulated blood (right) is shown. Median values are represented by solid lines. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Brent E. Palmer, PhD, Douglas G. Mack, PhD, Allison K"

Similar presentations

Impaired TH17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy 

Impaired TH17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy 
Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy  Erik Wambre, PhD, Jonathan.

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy  Erik Wambre, PhD, Jonathan.
Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS 
Comparison of the allergic and nonallergic CD4+ T-cell responses to the major dog allergen Can f 1  Suvi Parviainen, MSc, Antti Taivainen, MD, PhD, Aino.

Comparison of the allergic and nonallergic CD4+ T-cell responses to the major dog allergen Can f 1  Suvi Parviainen, MSc, Antti Taivainen, MD, PhD, Aino.
The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency  Rita Carsetti, MD, Maria Manuela Rosado, PhD, Simona.

The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency  Rita Carsetti, MD, Maria Manuela Rosado, PhD, Simona.
Defective calcium signaling and disrupted CD20–B-cell receptor dissociation in patients with common variable immunodeficiency disorders  Annick A.J.M.

Defective calcium signaling and disrupted CD20–B-cell receptor dissociation in patients with common variable immunodeficiency disorders  Annick A.J.M.
Expression of IL-9 receptor α chain on human germinal center B cells modulates IgE secretion  Lama M. Fawaz, PhD, Ehssan Sharif-Askari, PhD, Oumnia Hajoui,

Expression of IL-9 receptor α chain on human germinal center B cells modulates IgE secretion  Lama M. Fawaz, PhD, Ehssan Sharif-Askari, PhD, Oumnia Hajoui,
Flow cytometry imaging identifies rare TH2 cells expressing thymic stromal lymphopoietin receptor in a “proallergic” milieu  Amanda J. Reefer, MS, Kathryn.

Flow cytometry imaging identifies rare TH2 cells expressing thymic stromal lymphopoietin receptor in a “proallergic” milieu  Amanda J. Reefer, MS, Kathryn.
Correlation of allergen-specific T follicular helper cell counts with specific IgE levels and efficacy of allergen immunotherapy  Yin Yao, MD, Cai-Ling.

Correlation of allergen-specific T follicular helper cell counts with specific IgE levels and efficacy of allergen immunotherapy  Yin Yao, MD, Cai-Ling.
The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,

The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics  Elcio O. Vianna, MD, PhD, Jay Westcott, PhD,
Reduced TH1/TH17 CD4 T-cell numbers are associated with impaired purified protein derivative–specific cytokine responses in patients with HIV-1 infection 

Reduced TH1/TH17 CD4 T-cell numbers are associated with impaired purified protein derivative–specific cytokine responses in patients with HIV-1 infection 
Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use  Daniel A. Searing, MD, Yong Zhang, PhD, James.

Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use  Daniel A. Searing, MD, Yong Zhang, PhD, James.
Impaired TH17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy 

Impaired TH17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy 
Immunologic defects in 22q11.2 deletion syndrome

Immunologic defects in 22q11.2 deletion syndrome
Toll-like receptor 7–induced naive human B-cell differentiation and immunoglobulin production  Mark C. Glaum, MD, PhD, Shilpi Narula, MD, Decheng Song,

Toll-like receptor 7–induced naive human B-cell differentiation and immunoglobulin production  Mark C. Glaum, MD, PhD, Shilpi Narula, MD, Decheng Song,
Frank Kirstein, PhD, Natalie E

Frank Kirstein, PhD, Natalie E
Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome 

Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome 
T-cell regulation during viral and nonviral asthma exacerbations

T-cell regulation during viral and nonviral asthma exacerbations
Anti–IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL- 5 and IL-5 receptor levels  Miguel L. Stein, MD, Joyce M. Villanueva,

Anti–IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL- 5 and IL-5 receptor levels  Miguel L. Stein, MD, Joyce M. Villanueva,
Type 2 innate lymphoid cells in induced sputum from children with severe asthma  Prasad Nagakumar, MBBS, Laura Denney, PhD, Louise Fleming, MD, Andrew.

Type 2 innate lymphoid cells in induced sputum from children with severe asthma  Prasad Nagakumar, MBBS, Laura Denney, PhD, Louise Fleming, MD, Andrew.

Similar presentations

Ads by Google