Presentation is loading. Please wait.

Presentation is loading. Please wait.

Analytical Performance of a 15-Gene Prognostic Assay for Early-Stage Non–Small-Cell Lung Carcinoma Using RNA-Stabilized Tissue  Shuguang Huang, Nicholas.

Similar presentations


Presentation on theme: "Analytical Performance of a 15-Gene Prognostic Assay for Early-Stage Non–Small-Cell Lung Carcinoma Using RNA-Stabilized Tissue  Shuguang Huang, Nicholas."— Presentation transcript:

1 Analytical Performance of a 15-Gene Prognostic Assay for Early-Stage Non–Small-Cell Lung Carcinoma Using RNA-Stabilized Tissue  Shuguang Huang, Nicholas J. Reitze, Amy L. Ewing, Suzanne McCreary, Arlette H. Uihlein, Stacey L. Brower, Dakun Wang, Tianhua Wang, Michael J. Gabrin, Katherine E. Keating, Jude Mulligan, Claire Wilson, Timothy Davison, Stuart McKenzie, Ming-Sound Tsao, Frances A. Shepherd, Victoria Plamadeala  The Journal of Molecular Diagnostics  Volume 17, Issue 4, Pages (July 2015) DOI: /j.jmoldx Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

2 Figure 1 The risk scores from matched fresh-frozen (FF) and RNAlater tissues from non–small-cell lung carcinoma patients (n = 43). Each open circle represents the average risk score of two biological replicates within each tissue format. The dotted lines represent the clinically validated threshold between low (≤−0.1) and high (>−0.1) risk categories. The solid line is the 45° line. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

3 Figure 2 Risk scores from biological replicates of fresh frozen (FF) tissue from non–small-cell lung carcinoma patients (n = 43). Each open circle represents the risk score of each FF tissue within each of its biological replicates. The dotted lines represent the clinically validated threshold between low (≤−0.1) and high (>−0.1) risk categories. The solid line is the 45° line. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

4 Figure 3 Accuracy study results. Deming regression with Jackknife estimates of the SE. Each open circle represents the risk score of the same RNAL sample within the clinical and reference laboratories. The solid line is the estimated regression line. The dotted line is the 45° line. The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions


Download ppt "Analytical Performance of a 15-Gene Prognostic Assay for Early-Stage Non–Small-Cell Lung Carcinoma Using RNA-Stabilized Tissue  Shuguang Huang, Nicholas."

Similar presentations


Ads by Google