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Published byErika Walton Modified over 5 years ago
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Minor histocompatibility antigens in human stem cell transplantation
J.H.Frederik Falkenburg, Lisette van de Corput, Erik W.A Marijt, Roel Willemze Experimental Hematology Volume 31, Issue 9, Pages (September 2003) DOI: /S X(03)
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Figure 1 Proteins expressed in the cytosol or nucleus are degraded by the proteasome into smaller peptide fragments. These peptides can be N-terminally trimmed by aminopeptidases and subsequently translocated by the peptide pump “transporter in antigen processing” (TAP) over the membrane of the endoplasmic reticulum (ER). HLA class I molecules are synthesized and retained in the ER lumen until successful peptide binding occurs. These peptide/HLA complexes are subsequently transported to the plasma membrane. Experimental Hematology , DOI: ( /S X(03) )
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