1. Apparent diffusion coefficient mapping predicts mortality and outcome in rats with intracerebral haemodynamic disturbance: potential role of intraoperative diffusion and perfusion weighted magnetic resonance imaging to detect cerebral ischaemia 
S. Ishikawa, K. Yokoyama, T. Kuroiwa, K. Makita 
British Journal of Anaesthesia 
Volume 89, Issue 4, Pages (October 2002)
DOI: /bja/aef235
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
Diffusion-weighted image (upper left) and ADC map (upper right) during exsanguination, rCBV map (lower left), and rCBF map (lower right) of a representative rat in the 35 mm Hg group.
British Journal of Anaesthesia  , DOI: ( /bja/aef235)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
Sequential changes in ADC lesion volume in the ipsilateral (upper) and contralateral hemisphere (lower) of the 35 (black), 42 (grey), and 50 mm Hg (white) groups. Data are expressed as mean (sd). 0 min, 30 min represent 0 and 30 min after the completion of the infusion of the withdrawn blood, respectively. *P<0.05, **P<0.01 vs baseline. ##P<0.01 vs 42 mm Hg group. +P<0.05, ++P<0.01 vs 50 mm Hg group.
British Journal of Anaesthesia  , DOI: ( /bja/aef235)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
Low rCBV area (left) and low rCBF area (right) in the 35 (black), 42 (gray), and 50 mm Hg (white) groups. Data are expressed as mean (sd).
British Journal of Anaesthesia  , DOI: ( /bja/aef235)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

5. Fig 4
Relationships between ADC lesion area during exsanguination and low rCBV area and between ADC lesion area and low rCBF area on the coronal slice including the caudate putamen. There was a significant linear relationships between ADC lesion area and low rCBV area (y=0.58x+3.3 (r=0.73, P<0.01), dashed line) and ADC lesion area and low rCBF area (y=0.77x+2.2 (r=0.85, P<0.01), thick line).
British Journal of Anaesthesia  , DOI: ( /bja/aef235)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

6. Fig 5
ADC lesion volume during exsanguination (upper) and after re-infusion of blood (lower) in dead and survived rats. ADC lesion volumes in dead animals were significantly larger than those animals who survived in both periods. Horizontal lines indicate median values.
British Journal of Anaesthesia  , DOI: ( /bja/aef235)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

7. Fig 6
Histopathologic findings of the ipsilateral cortex in experimental rats 3 days after the MRI study (hematoxylin & eosin, original magnification ×400). (Left) Intact neurones, (right) dark neurones. Dark neurones were seen in the rats with a neuronal damage score of 1 or 2 predominantly in the border zone area.
British Journal of Anaesthesia  , DOI: ( /bja/aef235)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

8. Fig 7
ADC lesion area during exsanguination of dead animals and rats with neuronal damage score 0, 1, and 2. ADC lesion areas of the animals which were dead or showed neuronal damage score 2 was more than 14 mm2 (dashed line) but those of the rats whose neuronal damage score was 0 or 1 were less than 11 mm2.
British Journal of Anaesthesia  , DOI: ( /bja/aef235)
Copyright © 2002 British Journal of Anaesthesia Terms and Conditions