1. Multiple Choice Test Tips
EXAM
Lectures 1 to 9 are covered (that includes today)
Wednesday Help Session (optional)
90 minute test
LILY 1105
Multiple Choice Test Tips
Go through the test once and answer all the questions
Move on if you get stuck
Save some time at the end to double-check
Change your answers if you wish; research shows that most students gain more than they lose on changes answers. This advice is very dependent on the person feel free to ignore!

2. Major Histocompatibility Complex
Genetic region containing large number of different immune
related genes
Cell Surface molecules that were first associated with transplantation
histocompatibility antigens
transplantation antigens
Histo = tissue
Normal genes that do not rearrange (somatic recombination)
MHC genes are expressed co-dominantly (both copies are expressed)

3. Major Histocompatibility Complex
In humans the MHC locus is called the HLA complex and is located on Chromosome 6
In mice the MHC locus is called the H-2 complex and is located on chromosome 17
Each locus is further subdivided into 3 regions:
Class I MHC region - Present antigen to CD8+ Cytotoxic T-cells
Class II MHC region - Present antigen to CD4+ Helper T-cells (professional APCs)
Class III MHC region - Usually secreted proteins such as complement and cytokines