1. Cell-to-Cell Signaling
By Kristen Campbell
21 November 2002

2. Goals Definition of Cell Signaling Why is it important
Brief Discussion of the process
Signaling Types

3. What is Cell Signaling? Cell-Cell Communication Mediated by Signals
Signaling Types:
Contact Signaling
Long Range Signaling
Short Range Remote Signaling

4. Why is Cell Signaling Important ?
For Development of a Multicellular Organism you must have:
Regulation of Growth
Organization of tissues
Coordination of Function

5. Communication Involves 6 Steps
Synthesis of a Signaling Molecule
Release of the Signaling Molecule
Transport of the Signal to Target Cell
Detection by Specific Receptor Protein
Change in Cellular Function or Development
Removal of Signal

6. Types of Signaling Contact Signaling Long Range Signaling
Short Range Remote Signaling

7. Contact Signaling:
Tight Junctions
Desmosomes
Gap Junctions

8. Tight Junctions

9. Desmosomes

10. Gap Junctions

11. Distant Signaling: Endocrine Signaling Paracrine Signaling
Autocrine Signaling
Signaling by Plasma Membrane Proteins

12. Endocrine Signaling

13. Paracrine Signaling

14. Autocrine Signaling

15. Signaling by Membrane Proteins

16. Summary Definition of Cell Signaling Why Cell Signaling is Important
Steps involved in Cell Signaling
Types of Cell Signaling

17. Discussion