1. Small Molecules, Big Effects: A Role for Chromatin-Localized Metabolite Biosynthesis in Gene Regulation 
Bryan A. Gibson, W. Lee Kraus 
Molecular Cell 
Volume 41, Issue 5, Pages (March 2011)
DOI: /j.molcel
Copyright © 2011 Elsevier Inc. Terms and Conditions

2. Figure 1
Chromatin-Localized Biosynthesis of Metabolites Can Provide Chromatin- and Transcription-Modifying Enzymes with the Cofactors they Need to Catalyze Their Essential Chemical Reactions
While bound to chromatin, metabolite producers (“synthases”; e.g., MATIIα) can synthesize small molecule cofactors (e.g., SAM) that are used by chromatin- and transcription-modifying enzymes (“effectors”; e.g., methyltransferases) to chemically modify histones and nonhistone proteins to alter gene expression. The synthase may be recruited by a DNA-bound transcription factor (“TF”; e.g., MafK) or the effector. The specific examples noted here are from Katoh et al. (2011).
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2011 Elsevier Inc. Terms and Conditions