1. Examples of normal tissue profiles.
Examples of normal tissue profiles. The figure shows staining patterns for four proteins with two images for each protein. The antibody HPR generated toward the CRIM-1 protein precursor whose gene is located on chromosome 2 shows a very selective staining with only a distinct positivity in kidney glomeruli (a) and positive trophoblastic cells in placenta (b). The antibody HPR generated toward the melanoma antigen family B, 10 located on the X chromosome shows a strong and distinct staining in blood vessels including small intricate capillaries in the myocardium (c). The small arterioles in the kidney show positive staining, although specialized vasculature in the glomerulus is negative (d). The antibody HPR directed toward an unknown gene product (NP_ ) from chromosome 22 shows a selective and distinct staining in a subset of neuronal cells including the Purkinje cells in cerebellum (e) as well as a distinct and apparent fiber-specific staining in striated muscle fibers (f). The antibody HPR generated from the KCND1 gene located on the X chromosome shows a moderate cytoplasmic and membranous staining in several tissues including liver (g). A peculiar pattern of immunoreactivity was evident in heart tissue where several cardiomyocytes showed a condensed irregular sarcoplasmic positivity (h).
Mathias Uhlén et al. Mol Cell Proteomics 2005;4:
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