1. Nicotine inhibits hippocampal and striatal acetylcholinesterase activities, and demonstrates dual action on adult neuronal proliferation and maturation 
Omamuyovwi M. Ijomone, Polycarp U. Nwoha 
Pathophysiology 
Volume 22, Issue 4, Pages (December 2015)
DOI: /j.pathophys
Copyright © 2015 Elsevier B.V. Terms and Conditions

2. Fig. 1
AChE activities in hippocampus following nicotine treatment. Top: ImageJ count of AChE +ve cells in hippocampus (CA3). Values are expressed as mean±SEM. ***P< One way ANOVA followed by SNK post hoc. Bottom: representative photomicrographs of AChE +ve cells (arrows) in the hippocampus (CA3) of control — A, and nicotine treated; 0.25mg/kg — B, 2mg/kg — C and 4mg/kg — D. Observe the decrease in AChE positive cells following 2 and 4mg/kg of nicotine treatment. Scale bars — 50μm.
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2015 Elsevier B.V. Terms and Conditions

3. Fig. 2
AChE activities in striatum following nicotine treatment. Top: ImageJ count of AChE +ve cells in striatum (CPu). Values are expressed as mean±SEM. ***P< One way ANOVA followed by SNK post hoc. Bottom: representative photomicrographs of AChE +ve cells (arrows) in the Striatum (CPu) of control — A, and nicotine treated; 0.25mg/kg — B, 2mg/kg — C and 4mg/kg — D. Observe the decrease in AChE positive cells following 2 and 4mg/kg of nicotine treatment. Scale bars — 50μm.
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2015 Elsevier B.V. Terms and Conditions

4. Fig. 3
Ki67 immunoreactivity in hippocampus following nicotine treatment. Top: ImageJ count of Ki67 +ve cells in hippocampus (DG). Values are expressed as mean±SEM. * P<0.05, ** P<0.01. One way ANOVA followed by SNK post hoc. Bottom: representative photomicrographs of Ki67 +ve immunoreactive cells (arrows) in the hippocampus (DG) of control — A, and nicotine treated; 0.25mg/kg — B, 2mg/kg — C and 4mg/kg — D. Observe the decrease in Ki67 +ve immunoreactivity following 0.25 and 4mg/kg of nicotine treatment. Scale bars — 50μm.
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2015 Elsevier B.V. Terms and Conditions

5. Fig. 4
GFAP immunoreactivity in hippocampus following nicotine treatment. Top: ImageJ count of GFAP +ve cells in hippocampus (DG). Values are expressed as mean±SEM. One way ANOVA followed by SNK post hoc. Bottom: representative photomicrographs of GFAP +ve immunoreactive cells (arrows) in the hippocampus (DG) of control — A, and nicotine treated; 0.25mg/kg — B, 2mg/kg — C and 4mg/kg — D. Observe the similar GFAP +ve immunoreactivity in control and nicotine-treated groups. Scale bars — 50μm.
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2015 Elsevier B.V. Terms and Conditions

6. Fig. 5
NSE immunoreactivity in hippocampus following nicotine treatment. Top: ImageJ count of NSE +ve cells in hippocampus (DG). Values are expressed as mean±SEM. * P<0.05, ** P<0.01. One way ANOVA followed by SNK post hoc. Bottom: representative photomicrographs of NSE +ve immunoreactive cells (arrows) in the Hippocampus (DG) of control — A, and nicotine treated; 0.25mg/kg — B, 2mg/kg — C and 4mg/kg — D. Observe the decrease in NSE +ve immunoreactivity following 0.25 and 4mg/kg of nicotine treatment and increased NSE +ve immunoreactivity at 2mg/kg treatment. Scale bars — 50μm.
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2015 Elsevier B.V. Terms and Conditions