1. How was cps-6 identified as a factor important for paternal mitochondrial elimination ?
By genetic screen
By candidate-based RNAi screen
By educational guess
By pure luck
By biochemical purification

2. Where does cps-6 act to promote PME?
In the oocyte
In paternal mitochondria
In maternal mitochondria
In the autophagosome
In the nucleus of the oocyte

3. Based on the results in the paper, CPS-6 is important for
Degradation of paternal mtDNA
Recruitment of the autophagosome to paternal mitochondria
Degradation of paternal mitochondrial proteins
All of the above
A & B

4. How are paternal mitochondria selectively targeted for degradation in the fertilized eggs?
A. They look different from maternal mitochondria
B. Both paternal and maternal mitochondria are targeted for degradation
C. Paternal mitochondria are depolarized and damaged soon after their entry into the oocyte and thus marked for degradation
Paternal mitochondria are smaller than maternal mitochondria and thus are easier to be degraded by the autophagosome
Paternal mitochondria are larger than maternal mitochondria and thus can be readily recognized and degraded.

5. What are the important questions that remain to be addressed?

6. Why paternal mitochondria need to be eliminated from fertilized eggs ?
A. They are larger than maternal mitochondria and thus not compatible
Maternal mitochondria can do without paternal mitochondria
They have a higher frequency of mutations and thus are evolutionarily undesirable for embryo development
They actually don’t need to be eliminated.
None of the above