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The effect of TLR4 blockade on HMGB1 induced changes in tenocytes in vitro. The effect of TLR4 blockade on HMGB1 induced changes in tenocytes in vitro.

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Presentation on theme: "The effect of TLR4 blockade on HMGB1 induced changes in tenocytes in vitro. The effect of TLR4 blockade on HMGB1 induced changes in tenocytes in vitro."— Presentation transcript:

1 The effect of TLR4 blockade on HMGB1 induced changes in tenocytes in vitro.
The effect of TLR4 blockade on HMGB1 induced changes in tenocytes in vitro. The levels of mRNA for TLR4, IL-1β, CCl-2, IL-33, CXCL-12, IL-6 and TGF-β and Tenascin C, Decorin, Collagen 1 and Collagen 3 were determined by real-time PCR following transfection with a validated predesigned TLR4 siRNA or non-specific control siRNA for 48 hours using Lipofectamine Data are shown as the mean ± SEM of triplicate samples and represent experiments on five individual normal hamstring tendon patient explant samples utilising 18S housekeeping versus control. *p<0.05, **p<0.01 versus control (ANOVA). ANOVA, analysis of variance; HMGB1, high-mobility group protein B1; IL-1β, interleukin 1 beta; TGF-β, transforming growth factor beta. Moeed Akbar et al. RMD Open 2017;3:e000456 Copyright © BMJ Publishing Group & EULAR. All rights reserved.

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Supplementary Figure S4

Supplementary Figure S4
Supplemental Digital Content 4

Supplemental Digital Content 4
Monthly improvements in family, social and leisure activities to week 96 (last observation carried forward imputation). Assessed using the arthritis-specific.

Monthly improvements in family, social and leisure activities to week 96 (last observation carried forward imputation). Assessed using the arthritis-specific.
Monthly improvements in paid work productivity: overall axial spondyloarthritis population (employed patients only; last observation carried forward imputation). Assessed.

Monthly improvements in paid work productivity: overall axial spondyloarthritis population (employed patients only; last observation carried forward imputation). Assessed.
Ex vivo effects of proNGF and NGF on JIA mononuclear cells.

Ex vivo effects of proNGF and NGF on JIA mononuclear cells.
Partial knockdown of MPST markedly attenuates while overexpression of MPST exacerbates FFA-induced fat accumulation in hepatocyte in vitro. Partial knockdown.

Partial knockdown of MPST markedly attenuates while overexpression of MPST exacerbates FFA-induced fat accumulation in hepatocyte in vitro. Partial knockdown.
Oligonucleotide sequences of polymerase chain reaction (PCR) primers and competitive templates. Oligonucleotide sequences of polymerase chain reaction.

Oligonucleotide sequences of polymerase chain reaction (PCR) primers and competitive templates. Oligonucleotide sequences of polymerase chain reaction.
Conversion to ACPA and RF seronegative status in patients with early RA treated with abatacept+MTX compared with MTX alone. Conversion to ACPA and RF seronegative.

Conversion to ACPA and RF seronegative status in patients with early RA treated with abatacept+MTX compared with MTX alone. Conversion to ACPA and RF seronegative.
Time to discontinuation of TNF-inhibitors (TNF-i) and non-TNF-inhibitors (non-TNFi), non-adjusted (non-adj) and adjusted (adj) for propensity score survival.

Time to discontinuation of TNF-inhibitors (TNF-i) and non-TNF-inhibitors (non-TNFi), non-adjusted (non-adj) and adjusted (adj) for propensity score survival.
Percentage of patients achieving EULAR response

Percentage of patients achieving EULAR response
p75NTR, TrkA and sortilin expression levels in patients with JIA

p75NTR, TrkA and sortilin expression levels in patients with JIA
ASAS 20/40 response rates, and mean change from baseline in BASDAI through week 156* of treatment. *For patients who discontinued, the end of treatment.

ASAS 20/40 response rates, and mean change from baseline in BASDAI through week 156* of treatment. *For patients who discontinued, the end of treatment.
Endochondral bone formation in HLA-B27 transduced ATDC5 micromasses.

Endochondral bone formation in HLA-B27 transduced ATDC5 micromasses.
Association of disease parameters at the time of methotrexate reinitiation during the OLE based on propensity score matching. Association of disease parameters.

Association of disease parameters at the time of methotrexate reinitiation during the OLE based on propensity score matching. Association of disease parameters.
Flow diagram of the literature search process, including exclusions and reasons for exclusions. *Population of pregnant women (n=2), asymptomatic antiphospholipid.

Flow diagram of the literature search process, including exclusions and reasons for exclusions. *Population of pregnant women (n=2), asymptomatic antiphospholipid.
IFN-β, IL-6, TNF-α and CCL2 release were determined by ELISA in culture supernatants of PBMC stimulated with LPS from Salmonella abortusequi (1 µg/mL Sigma–Aldrich.

IFN-β, IL-6, TNF-α and CCL2 release were determined by ELISA in culture supernatants of PBMC stimulated with LPS from Salmonella abortusequi (1 µg/mL Sigma–Aldrich.
VEGF is upregulated in the arterial wall of patients with biopsy-proven GCA but not in controls. VEGF is upregulated in the arterial wall of patients with.

VEGF is upregulated in the arterial wall of patients with biopsy-proven GCA but not in controls. VEGF is upregulated in the arterial wall of patients with.
Changes in clinical disease activity over 24 months on a continuous scale in SWEFOT trial participants randomised to triple therapy or anti-TNF with available.

Changes in clinical disease activity over 24 months on a continuous scale in SWEFOT trial participants randomised to triple therapy or anti-TNF with available.
Mean concentrations (mM) of PG1+2, PG3 and PG4+5 in patients with or without MTX-related toxicity at baseline, week 4 and week 24/26 in (A) CONCERTO and.

Mean concentrations (mM) of PG1+2, PG3 and PG4+5 in patients with or without MTX-related toxicity at baseline, week 4 and week 24/26 in (A) CONCERTO and.
ASAS 20/40 responses in anti-TNF-naïve and anti-TNF-IR subjects at weeks 52, 104 and 156. ASAS 20/40 responses in anti-TNF-naïve and anti-TNF-IR subjects.

ASAS 20/40 responses in anti-TNF-naïve and anti-TNF-IR subjects at weeks 52, 104 and 156. ASAS 20/40 responses in anti-TNF-naïve and anti-TNF-IR subjects.

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