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Cysteine-rich secretory protein 1 in seminal plasma: potential biomarker for the distinction between obstructive and nonobstructive azoospermia  Christine.

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Presentation on theme: "Cysteine-rich secretory protein 1 in seminal plasma: potential biomarker for the distinction between obstructive and nonobstructive azoospermia  Christine."— Presentation transcript:

1 Cysteine-rich secretory protein 1 in seminal plasma: potential biomarker for the distinction between obstructive and nonobstructive azoospermia  Christine Légaré, M.Sc., Francine Cloutier, R.T., Sun Makosso-Kallyth, Ph.D., Nathalie Laflamme, Ph.D., Keith Jarvi, M.D., Roland R. Tremblay, M.D., Robert Sullivan, Ph.D.  Fertility and Sterility  Volume 100, Issue 5, Pages (November 2013) DOI: /j.fertnstert Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Relative amount of cysteine-rich secretory protein 1 (CRISP1)/prostatic phosphatase acid (PAP) in the seminal plasma of normal and azoospermic semen samples. (A) Representative Western blot of CRISP1/PAP detection. (B) Distribution of CRISP1/PAP in healthy (normal) donors (n = 30) and azoospermic donors (n = 52). Median values are indicated by horizontal bars. CRISP1/PAP levels in healthy (normal) donors and azoospermic patients show significant differences (P<.0001). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Distribution of seminal cysteine-rich secretory protein 1 (CRISP1)/prostatic phosphatase acid (PAP) in healthy (normal) donors (n = 15), nonobstructive azoospermia (NOA) donors (n = 14), and obstructive azoospermia (OA) donors (n = 14). Mean values are indicated by horizontal bars. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 Receiver operating characteristic (ROC) curve of the ability of seminal cysteine-rich secretory protein 1 (CRISP1)/prostatic phosphatase acid (PAP) levels and neutral alpha-glucosidase (NAG) activity to differentiate the nonobstructive azoospermia (n = 14) cases from the obstructive azoopermia cases (n = 14). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

5 Figure 4 Linear regression of cysteine-rich secretory protein 1 (CRISP1)/prostatic phosphatase acid (PAP) and neutral alpha-glucosidase activity in healthy (n = 45) and azoospermic samples (n = 79); P<.0001. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions


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