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Pharmacokinetics and safety of multiple oral doses of sustained-release 4- aminopyridine (fampridine-sr) in subjects with chronic, incomplete spinal cord.

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Presentation on theme: "Pharmacokinetics and safety of multiple oral doses of sustained-release 4- aminopyridine (fampridine-sr) in subjects with chronic, incomplete spinal cord."— Presentation transcript:

1 Pharmacokinetics and safety of multiple oral doses of sustained-release 4- aminopyridine (fampridine-sr) in subjects with chronic, incomplete spinal cord injury 1  Keith C Hayes, PhD, Patrick J Potter, MD, Jane T Hsieh, MSc, Mitchell A Katz, PhD, Andrew R Blight, PhD, Ron Cohen, MD  Archives of Physical Medicine and Rehabilitation  Volume 85, Issue 1, Pages (January 2004) DOI: /S (03)

2 Fig 1 Mean plasma concentrations by time and dosage level for the 11 subjects completing the study. Abbreviation: bid, twice daily. Archives of Physical Medicine and Rehabilitation  , 29-34DOI: ( /S (03) )

3 Fig 2 Mean Cmax and AUC0–12 versus Fampridine-SR dosage level for the 11 subjects completing the study. Vertical bars represent ±standard deviation. Archives of Physical Medicine and Rehabilitation  , 29-34DOI: ( /S (03) )


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