1. Host–microbiota interactions that regulate physiological and pathological immunity
Host–microbiota interactions that regulate physiological and pathological immunity A healthy diet and physiological microbiota regulate physiological immunity that also controls microglia homeostasis in the central nervous system including the retina. Prolonged high‐fat diet and obesity can cause dysbiosis with impairment of the gut barrier and systemic inflammation. Microbial molecular pattern molecules and pro‐inflammatory cytokines appear in the systemic circulation and trigger immune responses in the retina. Microglia reactivity and inflammatory macrophage recruitment support the pro‐angiogenic milieu and finally lead to enhanced CNV.
Rebecca Scholz, and Thomas Langmann EMBO Mol Med. 2016;emmm
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