1. Infliximab versus ciclosporin for steroid-resistant acute severe ulcerative colitis (CONSTRUCT): a mixed methods, open-label, pragmatic randomised trial 
Prof John G Williams, FRCP, M Fasih Alam, PhD, Laith Alrubaiy, PhD, Ian Arnott, FRCP, Clare Clement, MSc, Prof David Cohen, MPhil, John N Gordon, DM, A Barney Hawthorne, DM, Mike Hilton, BA, Prof Hayley A Hutchings, PhD, Aida U Jawhari, PhD, Mirella Longo, PhD, John Mansfield, MD, Jayne M Morgan, BSc, Prof Frances Rapport, PhD, Anne C Seagrove, PhD, Shaji Sebastian, FRCP, Ian Shaw, MSc, Prof Simon P L Travis, FRCP, Alan Watkins, PhD 
The Lancet Gastroenterology & Hepatology 
Volume 1, Issue 1, Pages (September 2016)
DOI: /S (16)
Copyright © 2016 Williams et al. Open Access article distributed under the terms of CC BY Terms and Conditions

2. Figure 1 Patients included in primary outcome analysis
BCC=basal-cell carcinoma. IBD=inflammatory bowel disease. RP=research professional. RCT=randomised controlled trial.
The Lancet Gastroenterology & Hepatology 2016 1, 15-24DOI: ( /S (16) )
Copyright © 2016 Williams et al. Open Access article distributed under the terms of CC BY Terms and Conditions

3. Figure 2 Patients included in follow-up
PFQ=participant follow-up questionnaire.
The Lancet Gastroenterology & Hepatology 2016 1, 15-24DOI: ( /S (16) )
Copyright © 2016 Williams et al. Open Access article distributed under the terms of CC BY Terms and Conditions

4. Figure 3
CUCQ score (A), SF-6D score (B), and EQ-5D score (C) over time
Data are mean score (95% CI) for each group.
The Lancet Gastroenterology & Hepatology 2016 1, 15-24DOI: ( /S (16) )
Copyright © 2016 Williams et al. Open Access article distributed under the terms of CC BY Terms and Conditions

5. Figure 4 Time to colectomy
The Lancet Gastroenterology & Hepatology 2016 1, 15-24DOI: ( /S (16) )
Copyright © 2016 Williams et al. Open Access article distributed under the terms of CC BY Terms and Conditions

6. Figure 5 Duration of treatment
The Lancet Gastroenterology & Hepatology 2016 1, 15-24DOI: ( /S (16) )
Copyright © 2016 Williams et al. Open Access article distributed under the terms of CC BY Terms and Conditions