1. Tablets Lecturer: dr. Asmaa abdelaziz Mohamed Faculty of pharamcay
Ibn hayan University 1

2. General Introduction Tablets
is defined as a compressed solid dosage form containing medicaments with or without excipients
Role in therapy
Oral solid forms are preferred class of product because of the following:
Accurate dose
Less expensive to ship without breakage or leakage
Bitter taste could be masked by coating
Portable
More stable chemically and physically 2

3. Advantages Greatest dose precision and least variability
the lowest cost
the lightest and most compact of all oral dosage forms
easy to scale up in production
convenience in packaging, shipping and dispensing
portability
ease of administration
Sustained release product is possible by enteric coating. 3

4. disadvantages
1-some drugs resist compression into tab because of its amorphous nature or low density character
2-drugs with poor wettability, slow dissolution may be difficult to formulate
3- bitter testing drugs or drugs with objectionable odour or drugs  that are sensitive to oxygen may require encapsulation or coating.  In such cases, capsule may offer the best and lowest cost. 
4-Difficult to swallow in case of children and unconscious patients.  4

5. Challenges in Formulation and manufacture
difficulty in achieving good bioavaiability in case of drugs with poor wetting and slow dissolution
difficulty of compaction for amorphous drugs 5

6. Evaluation 1- General Appearance 2- Size & Shape
3-Unique identification marking 6

7. Evaluation 4-Organoleptic properties 5-Weight variation 6-Friability
7-Hardness
3-Unique identification marking
8-Disintegration time:
9-Dissolution rate:
10-Content Uniformity Test 7

8. Evaluation 4-Organoleptic properties 5-Weight variation 6-Friability
7-Hardness
3-Unique identification marking
8-Disintegration time:
9-Dissolution rate:
10-Content Uniformity Test 8

9. Evaluation 8-Disintegration time: 4-Organoleptic properties
Tablets into smaller particles or granules
3-Unique identification marking
4-Organoleptic properties
5-Weight variation
6-Friability
7-Hardness
9-Dissolution rate:
10-Content Uniformity Test 9

10. Evaluation 9-Dissolution rate:
It is the dissolved percent of drug per time
3-Unique identification marking
4-Organoleptic properties
5-Weight variation
6-Friability
7-Hardness
8-Disintegration time:
10-Content Uniformity Test 10

11. EVALUATION SINKERS 10- Content Uniformity Test
Mesh Basket Sinker, With Lid
10- Content Uniformity Test
WIRE HELIX 11

12. Thank you