1. Immunogenetics chapter 22 select topics pp. 611-620

2. Topic Outline Overview of the Immune System
1st and 2nd lines of Defense
The Immune System
B cells
The antibody & antibody diversity
Vaccinations
Breast Feeding
Diagnostic applications
T cells
Allergies

3. Lines of Defense Physical and Chemical Immune system 1st and 2nd lines
3rd line

4. First line of defense

5. Second line of defense
Inflammation
Phagocytic cells
complement

6. 3rd line of defense “The Immune System”

7. Summary Lines of Defense
INNATE
ACQUIRED

8. Immune System
B cells
T cells

10. Lymph nodes are contain high concentrations lymphocytes

11. Let’s look more closely at the B lymphocytes

12. B Cell: humoral or antibody mediated immunity ANTIBODIES=IMMUNOGLOBULINS
Humoral Immunity
Matures in bone marrow
Moves to lymph nodes (& other locations)
Secretes antibodies “as plasma cell”
Also creates “memory” B cells
B-lymphocyte

13. CLONAL SELECTION

14. Different classes of immunoglobulins or antibodies
IgA
IgM
IgG
IgE
IgD

15. Antibody Diversity
How do we acquire so many different types of antibodies?
Somatic recombination
Junctional diversity
hypermutations

16. V J C
Antibody genes are composed of segments

18. Somatic Recombination

19. How are vaccinations related to immunity?
Active and Passive

20. Active Vaccinations: Antibody Production
Memory Cells!

21. Onto T Cells
The next part gets tricky

22. All T cells require cell to cell contact

24. CD8+
CD4+

25. T Cells VJC (D) These are some of the General characteristics of the T
Cell receptor for antigen recognition.
VJC (D)
+ D in the beta chain

26. Cytotoxic T Cell and MHC I
Antigen presentation
CD8+ cell

27. Cytotoxic T cell= CD8+

28. Cytotoxic T cell= CD8+

29. Tissue Transplantation
MHC proteins differ between individuals

30. The major histocompatibility complex
is a large group of genes on chromosome 6

31. Helper T Cell and MHC II
Antigen presentation

32. B lymphocytes source of antibodies
Overview of T lymphocytes

33. Cancer cell being attacked by cytotoxic T cells
After release of perforin

35. Allergic Response I.

36. Allergies B cell also directly stimulated
IgE