1. High-intensity interval training enhances mitochondrial bioenergetics of platelets in patients with heart failure 
Cheng-Hsien Chou, Tieh-Cheng Fu, Hsing-Hua Tsai, Chih-Chin Hsu, Chao-Hung Wang, Jong-Shyan Wang 
International Journal of Cardiology 
Volume 274, Pages (January 2019)
DOI: /j.ijcard
Copyright © 2018 Elsevier B.V. Terms and Conditions

2. Fig. 1
Effects of high-intensity interval training (HIIT) on mitochondrial O2 consumption rate (OCR) and bioenergetics health index of the intact platelets in patients with heart failure. GHC, general health care; ATP, ATP-linked OCR; Leak, proton leak; OCR; RESERVE, the reserve capacity of OCR; ROX, residual O2 consumption. *P < 0.05, Pre-intervention vs. Post-intervention; +P < 0.05, HIIT vs. GHC. Values were mean ± SD.
International Journal of Cardiology  , DOI: ( /j.ijcard )
Copyright © 2018 Elsevier B.V. Terms and Conditions

3. Fig. 2
Effects of high-intensity interval training (HIIT) on mitochondrial O2 consumption rate (OCR) of the permeabilized platelets in patients with heart failure. GHC, general health care. FAO, fatty acid oxidation; FAO + CI, fatty acid oxidation + Complex I; FAO + CI + CII, fatty acid oxidation + Complex I + Complex II; ETS FAO+CI+CII, adding FCCP (carbonyl cyanide-p-trifluoromethoxyphenylhydrazone) after fatty acid oxidation + Complex I + Complex II; ETSCII, adding FCCP after Complex II; ETS, electron transport system; *P < 0.05, Pre-intervention vs. Post-intervention; Values were mean ± SD.
International Journal of Cardiology  , DOI: ( /j.ijcard )
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4. Supplemental Fig. 1
Graph showing measurement of mitochondrial O2 consumption rate (OCR) in platelets using a high-resolution respirometry (Oroboros O2K). (A) and (B), the OCR protocol in intact platelets (IP); (C) and (D), the OCR [substrate, uncoupler, inhibitor titration (SUIT)] protocol in permeabilized platelets (PP). Omy, oligomycin; FCCP, carbonyl cyanide-p-trifluoromethoxyphenylhydrazone; Rot, rotenone; AA, antimycin A; M, malate; C, palmitoyl-DL carnitine-HCl; Dig, digitonin; ADP, adenosine diphosphate; P, pyruvate; G, glutamate; S, succinate;. Pre-HIIT, before high-intensity interval training; Post-HIIT, after high-intensity interval training.
International Journal of Cardiology  , DOI: ( /j.ijcard )
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5. Supplemental Fig. 2
Relationship between aerobic capacity and mitochondrial bioenergetics of intact platelets in patients with heart failure. (A) ATP, ATP-linked O2 consumption rate (OCR); (B) ETS, capacity of electron transport system; (C) Reserve, the reserve capacity of OCR; Pre-HIIT, before high-intensity interval training; Post-HIIT, after high-intensity interval training; Pre-GHC, before general health care; Post-GHC, after general health care; VO2peak, peak oxygen consumption; OCR, mitochondrial O2 consumption rate.
International Journal of Cardiology  , DOI: ( /j.ijcard )
Copyright © 2018 Elsevier B.V. Terms and Conditions

6. Supplemental Fig. 3
Relationship between aerobic capacity and mitochondrial bioenergetics of the permeabilized platelets in patients with heart failure. (A) Basal; (B) FAO, fatty acid oxidation; (C) FAO + CI, fatty acid oxidation + Complex I; (D) FAO + CI + CII, fatty acid oxidation + Complex I + Complex II; (E) ETS FAO+CI+CII, adding FCCP (carbonyl cyanide-p-trifluoromethoxyphenylhydrazone) after fatty acid oxidation + Complex I + Complex II; (F) ETSCII, adding FCCP after Complex II; ETS, electron transport system; Pre-HIIT, before high-intensity interval training; Post-HIIT, after high-intensity interval training; Pre-GHC, before general health care; Post-GHC, after general health care; VO2peak, peak oxygen consumption; OCR, mitochondrial O2 consumption rate.
International Journal of Cardiology  , DOI: ( /j.ijcard )
Copyright © 2018 Elsevier B.V. Terms and Conditions